Searchable abstracts of presentations at key conferences in endocrinology

ea0029p1029 | Male Reproduction | ICEECE2012

Activation of selective human sperm functions by EGF and TGF-β3 is mediated by an ERK-depended mechanism

Band G. , Etkovitz N. , Breitbart H. , Naor Z.

Introduction: The signaling involved in ligand-stimulated spermatozoa is not yet clarified. Moreover, the main question in sperm biology is the identification of the sperm ligands. Analysis of the role of MAPK in mammalian sperm physiology is a prerequisite for assigning a role for MAPK in mammalian sperm functions. The unique opportunity to study ERK1/2 in human spermatozoa, which are differentiated cells lacking active transcriptional machinery, will enable to correlate it t...

ea0029p1336 | Pituitary Basic | ICEECE2012

Role of a preformed signalosome in GnRH-stimulated FAK and paxillin phosphorylation by ERK at focal adhesions: possible role in gonadotropes migration

Rahamim-Ben Navi L. , Dobkin-Bekman M. , Naor Z.

Introduction: We have recently described a preformed signalosome associated with the GnRH receptor (GnRHR), which undergoes dynamic rearrangement upon stimulation with GnRH. This signaling complex included c-Src, focal adhesion kinase (FAK), paxillin, vinculin, tubulin, caveolin-1, protein kinase C (PKC) δ, PKCε, PKCα, Ras, kinase suppressor of Ras-1 (KSR), MAPK kinase (MEK) 1/2, ERK1/2 and the GnRHR. To sort out the role of the signalosomes associated with the ...

ea0008oc15 | Neuroendocrinology and Reproduction | SFE2004

PGF2alpha -FP receptor signalling is a potential regulator of endometrial vascular function

Sales KJ , Williams ARW , Anderson RA , Naor Z , Jabbour HN

Prostaglandin F2a (PGF) receptor (FP) expression is up-regulated in neoplastic epithelial and perivascular cells in endometrial adenocarcinomas, indicating potential regulation of vascular function by PGF via the FP receptor. This study investigated the potential role of PGF-FP receptor signalling in modulating vascular function in endometrial adenocarcinomas.Endometrial biopsies were obtained in accordance with Ethics Committee guidance with ...

ea0009oc13 | Oral Communication 2: Reproduction and growth | BES2005

A novel autocrine/paracrine inside-out signalling pathway that cross-talk the prostanoid and GnRH receptors in pituitary cells

Naor Z , Naidich M , Pawson A , Morgan K , Battersby S , MacPherson S , Millar M , Jabbour H , Millar R

Pituitary gonadotropes (LH and FSH producing cells) are simultaneously exposed to numerous stimuli, which exert multiple signalling pathways that cross-talk with the GnRH receptor (GnRHR). A model downstream effector system is the prostanoid family. Hence, prostanoid receptors and GnRHR might cross-talk and affect the biological responses of the gonadotropes. Here we report the expression of prostaglandin (PG) PGE2 receptors EP1, EP2, EP3 and EP4, the PGF2</sub...