Searchable abstracts of presentations at key conferences in endocrinology

ea0041gp48 | Bone & Calcium Homeostasis (1) | ECE2016

Serum sclerostin levels are significantly higher in type 2 diabetes compared to latent autoimmune diabetes in adults regardeless the presence of metabolic syndrome

Napoli Nicola , Buzzetti Raffaella

Objective: Sclerostin, a circulating Wnt antagonist and a main negative regulator of bone formation, is increased in type 2 diabetes (T2DM). No data are available on latent autoimmune diabetes in adults (LADA) and whether sclerostin is affected by metabolic syndrome (MS) associated with T2DM or LADA. We evaluated serum sclerostin and bone turnover markers in LADA and T2DM in relation with MS.Research design and methods: This cross-sectional study include...

ea0081p337 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Roux-en-Y gastric bypass and vertical sleeve gastrectomy showed similar efficacy in achieving cardiometabolic composite target in subject with type 2 diabetes undergoing bariatric surgery

Monte Lavinia , Tuccinardi Dario , Rossini Giovanni , Watanabe Mikiko , Pozzilli Paolo , Napoli Nicola , Manfrini Silvia

Introduction: The American Diabetes Association (ADA) produced a triple composite outcome that summarizes the therapeutic targets of the three most prevalent complications of obesity: type 2 diabetes (T2D), hypertension and dyslipidemia (HbA1c <7.0%; LDL cholesterol<100 mg/dl and systolic blood pressure <130 mmHg). The present study primarily investigates the difference between VSG and RYGB in achieving the composite target one year after the surgery. The secondary...

ea0081ep191 | Calcium and Bone | ECE2022

Primary hyperparathyroidism in the setting of previous roux-en-Y gastric bypass: a case report

Monte Lavinia , Tuccinardi Dario , Strollo Rocky , Briganti Silvia , Rausa Donatella , Pozzilli Paolo , Napoli Nicola , Manfrini Silvia

Introduction: Primary hyperparathyroidism (PHPT) after roux-en-Y gastric bypass (RYGB) is poorly described. The diagnosis can be difficult as secondary hyperparathyroidism(SHPT) commonly occurs in patients after RYGB due to calcium hypoabsorption and vitamin D deficiency.Observation: We present the case of a 50-year-old female with a history of normocalcemic hyperparathyroidism and nephrolithiasis. In 2005 the patient had undergone RYGB. During the first...

ea0081ep1049 | Thyroid | ECE2022

Worsening dysphagia and dysphonia: a case report

Rausa Donatella , Briganti Silvia Irina , Rossini Giovanni , Monte Lavinia , Napoli Nicola , Manfrini Silvia

Premise: multinodular goiter and compressive symptoms in the neck could not be necessarily associated.Case-report: A 82-year-old woman diagnosed follicular lymphoma in 2017 reached to the Emergency Department in Agoust 2021 because of a progressive and worsening dysphagia and dysphonia, begun six weeks before. The patient complained a weight loss of about 8 kg due to the inability in feeding. Her medical history was relevant for thyroid goiter, known sin...

ea0038oc2.5 | Translational pathophysiology and therapeutics | SFEBES2015

Age at first major osteoporotic fracture in Danes aged 50 and over: influence of diabetes on mean age at fracture and 1 year mortality

Abrahamsen Bo , Rosengren Bjorn , Prieto-Alhambra Daniel , Napoli Nicola , Cooper Cyrus

Diabetes mellitus (DM) is associated with an increased risk of fractures in excess of what would be expected from age and BMD. Further, DM is associated with increased risk of mortality in patients with hip fractures and possibly also other osteoporotic fractures.Study population and methods: Patients aged 50 or over who were treated for fractures of the hip, forearm, humerus and spine over 6 years (2004–2009, n=146 256) not coded as road t...

ea0081ep588 | Endocrine-Related Cancer | ECE2022

Severe refractory nonislet cell tumor hypoglycemia and paraneoplastic hypercalcemia in a patient with pancreatic adenocarcinoma with neuroendocrine differentiation: a case report.

Rossini Giovanni , Tommaso Alfonso Maria Di , Rausa Donatella , Palermo Andrea , Tuccinardi Dario , Pozzilli Paolo , Napoli Nicola , Manfrini Silvia

Nonislet cell tumor hypoglycemia (NICTH) is a rare complication of malignancy characterized by overproduction of incompletely processed IGF-2 and subsequent stimulation of insulin receptors and increased glucose utilization. We report a patient with pancreatic adenocarcinoma with neuroendocrine differentiation who presented with NICTH and paraneoplastic hypercalcemia. A 51 year-old male was admitted to the ER for altered mental status and confusion. His blood glucose was 27 mg...

ea0073aep104 | Calcium and Bone | ECE2021

Evaluation of bone quality by dxa-based bone strain index in primary hyperparathyroidism

Tabacco Gaia , Naciu Anda Mihaela , Messina Carmelo , Rinaudo Luca , Cesareo Roberto , Falcone Stefania , Manfrini Silvia , Napoli Nicola , Bilezikian John , Ulivieri Fabio Massimo , Palermo Andrea

BackgroudPrimary hyperparathyroidism (PHPT) is associated with impaired bone quality and increased fracture risk. Reliable tools for the evaluation of bone quality parameters are not yet clinically available. Bone Strain Index (BSI) is a new metric for bone strength based on Finite Element Analysis from lumbar spine and femoral neck dual X-ray absorptiometry images.AimTo assess the lumbar spine (LS), femoral ...

ea0063gp20 | Calcium and Bone 1 | ECE2019

Clinical, biochemical and radiological profile of normocalcaemic hyperparathyroidism: a multicentric cross-sectional evaluation

Naciu Anda Mihaela , Tabacco Gaia , Falcone Stefania , Santonati Assunta , Maggi Daria , D'Onofrio Luca , Briganti Silvia Irina , Castellitto Domenico , Casini Alessandro , Pedone Claudio , Fabbri Andrea , Napoli Nicola , Pozzilli Paolo , Manfrini Silvia , Cesareo Roberto , Palermo Andrea

Background: The normocalcaemic hyperparathyroidism (NHPT) has been defined as a condition with persistently normal total and ionized calcium levels in the presence of high levels of PTH. The clinical aspects of NHPT have been evaluated in different cohorts but the interpretation of these findings is confounded by differing methods used to rule out secondary hyperparathyroidism and by the small number of NHPT subjects enrolled. Up to now, there is no information available that ...