Searchable abstracts of presentations at key conferences in endocrinology

ea0034p88 | Clinical practice/governance and case reports | SFEBES2014

Is demeclocycline safe and effective in the treatment of SIADH?

Mongolu Shiva , Nasruddin Azraai

Background: Demeclocycline is a well-known treatment for syndrome of inappropriate ADH secretion (SIADH). We studied the use of demeclocycline for treatment of SIADH in our hospital to assess its efficacy and safety.Materials and methods: A search was performed for all discharge summaries containing demeclocycline over period of 1 year. 40 results obtained of which five were excluded as demeclocycline was mentioned but not actually used. 35 admission epi...

ea0028p385 | Thyroid | SFEBES2012

T4 mono-therapy versus T4/T3 combination therapy: a local review

Page Georgina , Nasruddin Azraai

Background: It is well documented that some patients with hypothyroidism continue to be symptomatic despite normalisation of TSH levels with T4 mono-therapy. The Royal College of Physicians 2008 statement recommends that T4 alone should be used for the treatment of hypothyroidism with no recommendation for additional T3 therapy. However, the Internet has many reports of symptomatic benefit on combination therapy and patients may present to the outpatient clinic requesting T3 t...

ea0034p30 | Bone | SFEBES2014

An ectopic parathyroid adenoma presenting with reduced conscious level and severe hypertension

Wiebel Rediet , Lambert Kimberley , Nasruddin Azraai

A 77-year-old lady presented with reduced conscious state, dysphasia and profound confusion on a background of behavioural change and anorexia over the previous 10 days. She was previously independent with history of hypertension controlled on atenolol (100 mg). She was significantly hypertensive 200/100. Her serum calcium was elevated at 4.01 mmol/l (2.05–2.60). The serum parathyroid hormone (PTH) was also significantly elevated at 26 pmol/l (0.5–6.4) consistent wit...

ea0034p245 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Case report: the role of somatostatin analogue therapy in nesidioblastosis following Roux-en-Y bypass surgery

Manikandan Rajamani , Mongolu Shiva , Nasruddin Azraai

Background: Postprandial hyperinsulinemic hypoglycaemia due to nesidioblastosis is a significant and debilitating complication after Roux-en-Y gastric bypass surgery (RYGB). There is growing evidence suggesting this is due to increased incretin hormones secretion. Nesidioblastosis can be difficult to manage with variable response to different pharmacological therapies and some requiring partial/total pancreatectomy or revision of bypass surgery pouch. We present a patient who ...

ea0034p400 | Thyroid | SFEBES2014

A case of Hashimoto encephalitis in a patient with severe autoimmune hypothyroidism

Bujanova Jana , Mongolu Shiva , Nasruddin Azraai

We present a case of 76-year-old male who attended acute medical unit with 3 week history of confusion, slurred speech and reduced mobility. One month prior to his admission he was diagnosed with severe hypothyroidism with TSH of 100 mU/l and T4 of 1.9 pmol/l and significantly positive anti-peroxidase antibodies (561 IU/ml) and was started on 100 μg of levothyroxine by his GP. During his admission his confusion persisted despite antibiotics for presumed chest i...

ea0034p288 | Pituitary | SFEBES2014

A case of pancytopenia due to isolated ACTH deficiency successfully treated with hydrocortisone

Mongolu Shiva , Manikandan Rajamani , Bujanova Jana , Nasruddin Azraai

BackgroundPancytopenia due to hypopituitarism has been reported previously in the literature. Most of these case reports relate to hypopituitarism secondary to Sheehan’s syndrome. We report a case of isolated ACTH deficiency causing pancytopenia which was successfully treated with hydrocortisone replacement.Case history: A 71-year-old lady with a known history of treated hypothyroidism and learning disabilities was referred to...

ea0015p39 | Clinical practice/governance and case reports | SFEBES2008

Granuloma annulare: a rare association with autoimmune Addisons disease

Nasruddin Azraai , Pusalkar Pawan , Zachariah Sunil , Russell-Jones David

We describe our patient, a 50 year old lady who developed Addisons disease 10 years ago with typical signs and symptoms of weight loss, hyperpigmentation, tiredness and postural hypotension. She is under follow up at our clinic for last 4 years. Her identical twin was diagnosed with Addisons disease and hypothyroidism at age 27 and with Coeliac disease when she was 43. Both of them are positive for anti-adrenal and TPO antibodies.Our patient developed le...