Searchable abstracts of presentations at key conferences in endocrinology

ea0028p184 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2012

The adipocyte as an active source of PLA2 isoforms influenced by adiposity, depot specificity and Type 2 Diabetes Mellitus

Kumsaiyai Warunee , Harte Alison , Saravanan Ponnusamy , Kyrou Ioannis , Aldaghri Nasser , Al-Attas Omar , Kumar Sudhesh , Tripathi Gyanendra , McTernan Philip

Lipoprotein-associated phospholipase A2 (Lp-PLA2) is a member of the phospholipase A2 super family of enzymes that hydrolyse phospholipids, and is upregulated in arterial inflammation, obesity and cardiovascular disease. Secreted soluble Lp-PLA2 (sPLA2) increases arterial inflammation in addition to cytosolic calcium dependent PLA2 (cPLA2) and calcium independent PLA2 (iPLA2). These studies examined the influence of adipose tissue (AT) depots (abdominal subcutaneous (Abd Sc), ...