Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep1087 | Clinical case reports - Pituitary/Adrenal | ECE2017

A rare case of short-term postpartum primary adrenal insufficiency

Briner Myriam , Gattlen Christina , Kaindl Gunther , Kaufmann Martin Lukas , Zerkiebel Nic , Rudovich Natalia

Aims: Polyglandulare Autoimmune Sydnrome (PAS) is a rare disease and the development during pregnancy is seen even less often. PAS Type II presents with autoimmune adrenalitis and thyroiditis. Symptoms of adrenalitis such as hypotension and hyperpigmentation are overlapping with physiological manifestations during pregnancy making the diagnosis difficult.Clinical presentation: We are reporting the case of a 28-year old prima para prima gravida presenting...

ea0022p142 | Cardiovascular endocrinology and lipid metabolism | ECE2010

Insulin mediates the glucagon-induced decrease in atrial natriuretic peptide: a randomized controlled trial

Arafat Ayman , Rudovich Natalia , Adamidou Aikaterini , Spranger Joachim , Weickert Martin , Mohlig Matthias , Pfeiffer Andreas

Objectives: Atrial natriuretic peptide (ANP) is a cardiac hormone that is known to play an essential role in regulation of blood pressure and vascular endothelial function. However, the metabolic regulation of ANP is not fully understood. In patients suffering from metabolic syndrome hypertension, hyperinsulinemia and postprandial hyperglucagonemia are common features. It was the aim of the present study to evaluate the impact of glucagon on proANP and the possible mechanisms ...

ea0020p465 | Obesity and Metabolism | ECE2009

Glucose-dependent insulinotropic polypeptide modulates inflammatory markers in adipose tissue

Gogebakan Ozlem , Osterhoff Martin , Mosig Sandy , Middelbeck Ines , Rudovich Natalia , Schuler Rita , Pfeiffer AFH

Background: Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that is secreted in response to food intake. GIP acts on various tissues, including pancreatic ß-cells, via interaction with its G-protein-coupled receptor. Some studies in rodents suggested that GIP directly links overnutrition to obesity. GIP exerts a physiological role on lipid uptake into adipocytes.Objectives: To analyse the effect of GIP-Infusions on c...

ea0016p543 | Obesity | ECE2008

Glucose-dependent insulinotropic polypeptide (GIP) modulates inflammatory markers and regulates cell proliferation in subcutaneous adipose tissue

Gogebakan Ozlem , Mosig Sandy , Middelbeck Ines , Osterhoff Martin A , Isken Frank , Rudovich Natalia , Pfeiffer Andreas F H

Background: Glucose-dependent insulinotropic polypeptide (GIP) is a gastrointestinal hormone that is secreted in response to food intake and modulates β-cell function. Remarkably, GIP looses its insulinomimetic effect in the presence of chronic hyperglycaemia and thus appears to be ineffective in poorly controlled T2DM at least with regard to insulin release. The mechanism by which this occurs is not clear and it is not known.Objectives: To analyse ...

ea0022p713 | Obesity | ECE2010

Gastric inhibitory polypeptide (GIP) suppresses circulating ghrelin in humans: plasma metabolome based correlation network analysis for support of hormone-to- hormone interactions

Rudovich Natalia , Nikiforova Victoria J , Otto Baerbel , Pivovarova Olga , Gogebakan Ozlem , Weickert Martin O , Nauck Michael A , Pfeiffer Andreas F H

Aims: We investigate the influence of GIP on ghrelin secretion in normal glucose tolerant individuals with the use of the firstly applied correlation network analysis on human plasma metabolome data.Methods: To address this issue, we employed a GIP-infusion test and euglycemic- and hyperglycemic glucose clamp experiments combined with infusion of GIP or placebo in a cross-over manner in non diabetic obese male subjects (n=14). Moreover, we firstly...

ea0056p581 | Obesity | ECE2018

Plasma metabolomic markers of insulin resistance in humans.

Pivovarova Olga , Gahwiler Roman , Nikiforova Viktoria , von Loffelholz Christian , Lisec Jan , Erban Alexander , Zerkiebel Nic , Willmitzer Lothar , Pfeiffer Andreas F H , Weickert Martin O , Rudovich Natalia N

Introduction: Insulin resistance (IR), a pathological state of low sensitivity to insulin in humans and animlas, is closely associated with type 2 diabetes mellitus, obesity and cardiovasculare dieseas. IR can be quantified using detailed protocols, such as the euglycemic-hyperinsulinemic clamp (EC) technique and the intravenous glucose tolerance test, or based on indices derived from the oral glucose tolerance test. Although these indices showed greater association with the i...

ea0041oc12.3 | Obesity | ECE2016

Effects of weight loss and long-term weight maintenance with diets varying in protein and glycemic index on circulating pro-neurotensin in the Diet, Obesity, and Genes (DiOGenes) Study: a randomized, controlled trial

Rudovich Natalia , Bernigau Wolfgang , Pivovarova Olga , Osterhoff Martin , Sparwasser Andrea , Bergmann Andreas , Struck Joachim , van Baak Marleen A , Jebb Susan A , Papadaki Angeliki , Alfredo Martinez J , Handjieva-Darlenska Teodora , Kunesova Marie , Hager Jorg , Valsesia Armand , Viguerie Nathalie , Langin Dominique , Astrup Arne , Saris Wim H M , Pfeiffer Andreas F H

Aims: Elevated levels of neurotensin (NT), a neurotransmitter and postprandial secreted intestinal hormone, are associated with an increased risk of diabetes, cardiovascular disease and breast cancer. Here we studied the regulation of circulating pro-NT (a stable NT precursor fragment) by weight loss and dietary interventions.Methods: DiOGenes is a pan-European controlled dietary intervention study in overweight adults who first lost body weight on an 8-...