Searchable abstracts of presentations at key conferences in endocrinology

ea0041s23.2 | Indications of incretin based therapies | ECE2016

GLP-1 in type 2-diabetic patients

Nauck Michael

GLP-1 is one of the two known incretin hormones (the other one being GIP), which have the ability to stimulate insulin secretion whenever glucose concentrations are above a certain permissive threshold. The incretin effect (greater stimulation of insulin secretory responses with oral as compared to matched intravenous glucose administration) is reduced in patients with type 2 diabetes, thus the question needed to be addressed, whether there is hyposecretion or impaired action ...

ea0029pl7 | Diabetes as a gut disease | ICEECE2012

Diabetes as a gut disease

Nauck Michael A.

Gastric inhibitory polypeptide (GIP) is a physiologically important incretin hormone secreted from K cell of the upper small intestine. Glucagon-like peptide 1 (GLP-1) is secreted from L cells in the lower small and large intestine. Both hormones are released after nutrient (especially carbohydrate and fat) ingestion and glucose-dependently augment insulin secretion. An involvement of either incretin hormone in the pathogenesis of diabetes may, in principle, be related to abno...

ea0022p713 | Obesity | ECE2010

Gastric inhibitory polypeptide (GIP) suppresses circulating ghrelin in humans: plasma metabolome based correlation network analysis for support of hormone-to- hormone interactions

Rudovich Natalia , Nikiforova Victoria J , Otto Baerbel , Pivovarova Olga , Gogebakan Ozlem , Weickert Martin O , Nauck Michael A , Pfeiffer Andreas F H

Aims: We investigate the influence of GIP on ghrelin secretion in normal glucose tolerant individuals with the use of the firstly applied correlation network analysis on human plasma metabolome data.Methods: To address this issue, we employed a GIP-infusion test and euglycemic- and hyperglycemic glucose clamp experiments combined with infusion of GIP or placebo in a cross-over manner in non diabetic obese male subjects (n=14). Moreover, we firstly...