Searchable abstracts of presentations at key conferences in endocrinology

ea0032p974 | Steroid metabolism and action | ECE2013

Effects of food components and the ratio of epitestosterone to testosterone on steroid glucuronidation

Jenkinson Carl , Barker James , Petroczi Andrea , Naughton Declan

The ratio of the glucuronidated epitestosterone (E) and testosterone (T), used in doping tests, is currently under question. The key enzyme involved in E metabolism is UGT2B7 in contrast to T which is mainly metabolised by UGT2B17. Previous results demonstrated that at very high concentrations E acts as a competitive inhibitor to UGT2B17. Similarly, the literature reports competitive inhibition of UGTs by NSAIDS and phenolics that are not substrates of UGT2B17. The aim of this...

ea0032p125 | Calcium and Vitamin D metabolism | ECE2013

An observational study reveals that neonatal vitamin D is primarily determined by maternal contributions: implications of a new assay on the roles of vitamin D forms

Karras Spyridon , Shah Iltaf , Petroczi Andrea , Goulis Dimitrios , Bili Helen , Papadopoulou Fotini , Anagnostis Panagiotis , Persinaki Aggeliki , Tarlatzis Basil , Naughton Declan

Introduction: Vitamin D concentrations during pregnancy are measured to diagnose states of insufficiency or deficiency. The aim of this study is to apply accurate assays of vitamin D forms (single hydroxylated (25(OH)D2, 25(OH)D3), double-hydroxylated (1α,25(OH)2D2, 1α,25(OH)2D3), epimers (3-epi-25(OH)D2, 3-epi-25(OH)D3)) in mothers (serum) and neonates (umbilical cord) i) to expl...

ea0070ep559 | Hot topics (including COVID-19) | ECE2020

Effects of Orthodox fasting on cardiometabolic risk factors: a comparative evaluation between lay fasters and Athonian monks

Karras Spyridon , Koufakis Theocharis , Petróczi Andrea , Folkerts Dirk , Kypraiou Maria , Grammatiki Maria , Mulrooney Hilda , Naughton Declan , Skoutas Dimitrios , Adamidou Lilian , Zebekakis Pantelis , Kotsa Kalliopi

Background: Orthodox fasting (OF), a periodical vegetarian subset of the Mediterranean diet, has been shown to exert beneficial effects on human health. Athonian fasting is a pescetarian OF variation, where red meat is restricted throughout the year. Previous studies have examined the OF nutritional synthesis and health impact in general population fasters (GF) and Athonian monks (AM), separately. This is the first study to comparatively evaluate the characteristics and effect...