Endocrine Abstracts

Introduction: Type 2 diabetes mellitus (T2DM) affects bone metabolism, but its relation with bone mineral density (BMD) remains controversial. It is also known that T2DM is associated with hypogonadism in males. Male hypogonadism can also affect BMD. Thus the aim of this study was to evaluate BMD in male patients with T2DM with and without hypogonadism.Methods/design: Hypogonadism was defined as serum free Testosterone (fT) value <5 ng/dl or 5–9...

Introduction: Data on Vitamin B12 deficiency and its relationship with Gestational Diabetes Mellitus (GDM) andpregnancy outcomes are limited. The aim of the present study is to determine, in pregnant women with GDM, the association between Vitamin B12 levels and glycemic control, as well as with pregnancy outcomes.Methods: We studied 44 women with GDM, mean age 31.9 ± 5.8 years old, at the second trimester and at labor and measured weight, height, b...

Introduction: Existing data suggest that Type 1 Diabetes Mellitus (T1DM) can affect both hypothalamic-pituitary-testis axis and bone health. The mechanisms by which sex steroids influence bone remodeling remain incompletely understood. Data linking gonadal function and bone turnover in male patients with T1DM are lacking. The purpose of this study was to examine any possible association between sex steroids levels and parameters of bone assessment in male adult patients with T...

Introduction: Type 1 diabetes mellitus (T1DM) is associated with reduced bone mineral density (BMD) and increased bone turnover. However, data regarding the influence of glycemic control on bone are limited. The aim of this study was to evaluate BMD and bone remodeling markers in patients with T1DM in relation to changes in glycemic control.Methods/design: We studied 107 patients with T1DM (Group-D) (mean age: 34+8.1 years, M/F: 48/59) and 95 healthy con...

Introduction: Although patients with type 2 diabetes mellitus (T2DM) have normal or higher bone mineral density (BMD) comparing to healthy subjects, they appear to be at high risk of osteoporotic fractures. Factors that contribute to bone fragility in T2DM are not clearly understood. The aim of this study was to evaluate the influence of glycemic control on bones in T2DM.Methods/design: We studied 40 patients with T2DM (mean age: 54.3+3.2 years, M/F: 24/...

Introduction: Type 1 DM (T1DM) has been associated with low bone mineral density (BMD) measured by dual energy X-ray absorptiometry (DEXA) but not with quantitative computed tomography (QCT). QCT provides a three-dimensional image and measures bone’s volume directly as density, independent of the surrounding tissues. The purpose of this study was to evaluate BMD in patients with T1DM using DEXA and QCT.Methods/design: We studied 81 patients with T1D...

Introduction: Limited data exists regarding testosterone levels in type 1 diabetes mellitus (T1DM). The objective of this study was to evaluate serum sex steroids levels and body composition using dual energy X-ray absorptiometry method (DEXA) in male patients with T1DM.Methods/design: We studied 36 male patients with T1DM (group D) (age: 35.3+11.66, years) and 35 healthy control (group C) matched for age, sex, and BMI. In both groups waist circumference...