Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep900 | Pituitary - Clinical | ECE2016

Impact of the GH-receptor antagonist pegvisomant on mammographic breast density in postmenopausal acromegalic women

Muhammad Ammar , Ficarra Gianluca , Franck Sanne , Nazarri Elena , Tagliafico Alberto , Neggers Sebastian , Ferone Diego , Gatto Federico

Background: Acromegaly is a severe systemic condition characterized by elevated circulating levels of growth hormone (GH) and insulin-like growth factor I (IGF-I) and increased mortality and morbidity. The role of GH and IGF-I in mammary hyperplasia is well established and GH/IGF-I elevation has been hypothesized to favor neoplastic development. We recently demonstrated that premenopausal females with active acromegaly may display an increased mammographic breast density (MBD)...