Searchable abstracts of presentations at key conferences in endocrinology

ea0044p62 | Clinical biochemistry | SFEBES2016

Burden of major sodium and calcium abnormalities in the non-ITU adult inpatient population of a large two-site university hospital

Jones Philip , Mamoojee Yaasir , Neely Dermot , Quinton Richard

Background and aims: Electrolyte imbalance is common among hospital inpatients, reflecting severity of underlying illness, but also independently contributing to excess morbidity and mortality. However, studies have largely been retrospective, with incomplete data capture. We prospectively evaluated the prevalence of major Na and Ca disorders among inpatients at the Newcastle-upon-Tyne Hospitals.Method: With approval of the Information Guardian, we used ...

ea0038p19 | Clinical biochemistry | SFEBES2015

A comparison of plasma copeptin and AVP responses during saline infusion studies

Boot Christopher , Hughes Louise , Turner Stephen , Ball Stephen , Neely Dermot

Introduction: Copeptin is the C-terminal fragment of proAVP and secreted in equimolar amounts with AVP. While AVP is unstable in vitro and has proved difficult to measure in clinical practice, copeptin is relatively stable and can be measured using an automated immunoassay. Therefore copeptin measurement offers potential as a more practical alternative to the direct measurement of AVP in the investigation of polyuria/polydipsia.Methods: AVP, cop...

ea0038p31 | Clinical biochemistry | SFEBES2015

Single-centre audit of the diagnostic performance of plasma metanephrines with seated sampling for the diagnosis of phaeochromocytoma/paraganglioma

Boot Christopher , Toole Barry , Johnson Sarah , Ball Stephen , Neely Dermot

Introduction: Measurement of plasma metanephrines (PMETS) is widely regarded as one of the best screening tests for phaeochromocytoma/paraganglioma (P/PGL). Current Endocrine Society guidelines recommend that samples for PMETS are ideally collected in the supine position after 30 min rest and interpreted using supine reference ranges, in order to optimise the diagnostic performance of the test. Current practice in our centre is to collect samples for PMETS from seated patients...

ea0028p318 | Steroids | SFEBES2012

The cortisol response to hypobaric hypoxia at rest and post-exercise

Stacey Mike , Davison Andrew , Mellor Adrian , Smith Chris , Hooper Tim , Neely Dermot , Peaston Bob , Turner Steve , Woods David

High altitude exposure leads to a marked natriuresis and diuresis facilitated by a reduced resting and subdued post-exercise aldosterone. There is a strong correlation between aldosterone and cortisol at high altitude and although most, but not all, investigators report a rise in cortisol with ascent very little data exist regarding the post-exercise response in cortisol. We therefore measured salivary cortisol in a cohort of 45 subjects post-exercise and 20 subjects at rest w...