Searchable abstracts of presentations at key conferences in endocrinology

ea0063oc12.2 | Endocrine Connections 2 | ECE2019

Epigenetic programming of transgenerational hypertension in preterm birth mice

Dumeige Laurence , Nehlich Melanie , Viengchareun Say , Pussard Eric , Lombes Marc , Martinerie Laetitia

Renal and cardio-vascular complications of prematurity are well established, notably those associated with renal tubular immaturity, responsible for major salt loss at birth, as well as early hypertension in adulthood. However, the molecular underlying mechanisms remain poorly understood. Our objective was to investigate the impact of preterm birth on the ontogenesis of renal corticosteroid pathways, to evaluate its implication on perinatal complications and on the emergence o...

ea0049oc5.5 | Cardiovascular Endocrinology | ECE2017

Sex dimorphism of renal corticosteroid signaling during development and long term consequence on blood pressure

Dumeige Laurence , Storey Caroline , Decourtye Lyvianne , Nehlich Melanie , Lhadj Christophe , Viengchareun Say , Kappeler Laurent , Lombes Marc , Martinerie Laetitia

Sex differences have been demonstrated in various biological processes such as arterial blood pressure. However, the potential sex dimorphism of the renin-angiotensin-aldosterone system and, by extension, the mineralocorticoid receptor (MR) signaling pathway, major regulators of blood pressure, has only been poorly studied, notably in the kidney. Basal systolic blood pressure (SBP) and heart rate (HR) were measured in adult male and female mice. Renal gene expression studies o...