ea0021p304 | Pituitary | SFEBES2009
Walls Gerard
, Newey Paul
, Jeyabalan Jeshmi
, Nesbit A Michael
, Schulz Herbert
, Huebner Norbert
, Thakker Rajesh
Multiple endocrine neoplasia type 1 (MEN1) is an autosomal dominant disorder characterized by the occurrence of anterior pituitary, pancreatic islet and parathyroid tumours. Mice (Men1+/−) deleted for an MEN1 allele develop these tumours. The MEN1 gene encodes a 610 amino acid protein that has been reported to upregulate caspase 8 expression and promote apoptosis. To characterize the functional effects of menin loss in vivo, we asse...