Endocrine Abstracts

Background: In vitro fertilisation is an effective therapy for infertility, but can result in the potentially life-threatening complication, Ovarian Hyper-Stimulation Syndrome (OHSS). We have previously reported that a single injection of kisspeptin results in an LH surge of ~12–14 hrs duration, sufficient to safely induce oocyte maturation, but eliminate OHSS. However, the physiological LH surge in a normal menstrual cycle has a plateaux lasting 24–28 hrs. ...

Kisspeptin is a crucial activator of reproductive function, stimulating GnRH neurons in the hypothalamus. However, kisspeptin and its receptor are also expressed in other brain regions including the limbic system, which has key roles in emotional processing. Kisspeptin signalling in the limbic system modulates emotional and sexual brain processing during tasks, however the effects of kisspeptin on underlying resting brain activity have not yet been studied. This is vital for o...

Kisspeptin is a crucial activator of reproductive function, stimulating GnRH neurons in the hypothalamus. However, kisspeptin and its receptor are also expressed in other brain regions including the limbic system, which has key roles in emotional processing. Kisspeptin signalling in the limbic system modulates emotional and sexual brain processing during tasks, however the effects of kisspeptin on underlying resting brain activity have not yet been studied. This is vital for o...

Kisspeptin is a crucial activator of reproductive function, playing a critical role in the hypothalamus to activate GnRH neurons and downstream reproductive hormones. However, kisspeptin and its receptor are also expressed in other brain areas, yet little is known about their function here. The limbic system plays a key role in sexual and emotional behaviours and has a high expression of kisspeptin receptors. We therefore hypothesised that kisspeptin administration may modulat...