Endocrine Abstracts

Introduction: The purpose of this study was to evaluate the relation between menopausal women and the thiol/disulphide balance, used as a marker of oxidative stress, by measuring that exchange using a novel technique.Methods: Fourty five postmenopausal subject and 39 healthy participant were included in the study.Results: We found that in postmenopausal group, disulphide (P=0.04), disulphide/native thiol (P=0.004)...

Objective: To investigate dynamic thiol/disulphide homeostasis in autoimmune subclinical hypothyroidism.Materials and methods: 48 patients with newly diagnosed subclinical hypothyroidism due to Hashimoto’s thyroiditis and not yet on any treatment and 48 healthy subjects without any known disease were enrolled. Thiol/disulfide homeostasis (native thiol(-SH)–disulphide(-S-S-) exchanges) was measured in both groups with new method developed by Ere...

AimEuthyroid Sick Syndrome (ESS) is a thyroid disease appeared in critical and noncritical illnesses. ESS can be seen in patients with end stage renal disease (ESRD). In this study, we aimed to evaluate the frequency of ESS before and after renal transplantation in patients with ESRD, and its association with oxidative stress by evaluating thiol-disulphide levels.Material and MethodIn this study, free triiodo...

Objective: Thiols are organic compounds that contain sulphydryl group (-SH) and have important role in preventing oxidative stress especially in cells. The aim of our study is to investigate the relationship between hypothyroidism due to HT and the thiol disulfide homeostasis, the effect of treatment on this homeostasis and to demonstrate the utility of thiol/disulphide homestasis as a marker for assessing the damage to functional group of proteins and the oxidative balance in...

Background: Thiol/disulfide homeostasis plays an important role in antioxidative defense mechanism, detoxification, signal transport, management of enzyme activity and trascription factors, and apoptosis. When thiol/disulphide homeostasis breaks down, these important cellular functions get deranged. Pathologies secondary to oxidative stress are seen in organeles in which this homeostasis is deranged. The aim of the study was to investigate dynamic thiol/disulfide homeostasis i...