Searchable abstracts of presentations at key conferences in endocrinology

ea0033oc2.10 | Oral Communications 2 | BSPED2013

A new approach to the definition and diagnosis of adrenal insufficiency during inhaled corticosteroid therapy for asthma

Blair Jo , Didi Mohammed , Lancaster Gillian , Titman Andrew , Newland Paul , Collingwood Catherine , Peak Matthew , Couriel Jonathon

Background: Up to 50% of children treated with inhaled corticosteroids (ICS) have biochemical evidence of adrenal insufficiency (AI). Episodes of adrenal crisis (AC) are extremely rare.To address the discordance between the prevalence of biochemical AI and AC, we re-examined the biochemical definition of AI during ICS therapy. We then investigated the utility of early morning salivary cortisol (EMSC) and cortisone (EMSCn) for the identification of patien...

ea0023oc1.1 | Oral Communications 1 | BSPED2009

Cholesterol and apolipoprotein levels in a cohort of girls with Turner syndrome, and the effect of GH therapy

Gardner Chris , Garden Anne , Didi Mohammed , Newland Paul , Banerjee Indi , Blair Jo

Introduction: Ischaemic heart disease occurs seven times more frequently in women with Turner syndrome (TS) than the normal population. Adult TS subjects have raised serum cholesterol (Ch). In our service we measure Ch, apolipoprotein A1 (APA) and B (APB) annually in TS patients aged >5 years as APB:APA in childhood is a strong predictor of cardiovascular risk in adult life. Little is known about lipid profiles or the effects of GH or oestrogen (E2) in childhood...

ea0027p32 | (1) | BSPED2011

Steroid dose, age and gender affect adrenal responses to a low dose short Synacthen test in children with asthma

Hawcutt Daniel , Jorgensen Andrea , Gardner Christopher , Peak Matthew , Couriel Jonathan , Lacy David , Newland Paul , Didi Mohamed , Pirmohamed Munir , Smith Rosalind , Blair Joanne

Background: The activity of the hypothalamic┬ľpituitary┬ľadrenal axis (HPA) during inhaled corticosteroid (ICS) treatment of asthma has been studied extensively. To date patient populations have been too small or homogeneous to identify relationships between steroid exposure, patient characteristics and HPA activity. In this abstract we report data from a large, heterogeneous cohort of patients recruited to observational and pharmacogenomic studies.<p class="abstex...