Searchable abstracts of presentations at key conferences in endocrinology

ea0009p155 | Thyroid | BES2005

Expression of connective tissue growth factor in human thyroid tissue

Nguyen Q , Buchanan M , Watkinson J , Eggo M

Connective tissue growth factor (CTGF aka CCN2), is known to be up-regulated by transforming growth factor beta (TGF beta) and plays important roles in cell cycle control, growth, differentiation, cell adhesion, migration, angiogenesis and ECM production. CTGF is overexpressed in fibrotic disease e.g in kidney, lung, heart as well as in tumours. We have examined expression of CTGF in thyroid tissue because TGF beta is known be an autocrine factor, regulated by iodide. Immunohi...