ea0007p209 | Steroids | BES2004
Ye P
, Kenyon C
, Nichol K
, MacKenzie S
, Fraser R
, Seckl J
, Connell J
, Davies E
11Beta-Hydroxylase and aldosterone synthase catalyse the synthesis of corticosterone and aldosterone in the rat adrenal cortex and are encoded by the CYP11B1 and CYP11B2 genes respectively. These genes are also expressed in distinct regions of the CNS and cardiovascular system where they may play a key role in behavioural response and blood pressure homeostasis. However, it is unclear whether this extra-adrenal expression is regulated by, or contributes to, circulating levels ...