Searchable abstracts of presentations at key conferences in endocrinology

ea0014p91 | (1) | ECE2007

Impaired proinsulin secretion before and during oral glucose stimulation in HIV-infected patients, who display fat redistribution

Haugaard Steen B , Andersen Ove , Halsall Ian , Iversen Johan , Nicholas Hales Charles , Madsbad Sten

Beta-cell function of HIV-infected patients on highly active antiretroviral therapy (HAART), who display lipodystrophy, may be impaired. An early defect in beta-cell function may be characterized by an increased secretion of 32–33 split proinsulin (SP) and intact proinsulin (IP).To address this issue the secretion pattern of SP and IP of 16 HIV-infected men with lipodystrophy (LIPO) and 15 HIV-infected men without lipodystrophy (NONLIPO) were studie...