Searchable abstracts of presentations at key conferences in endocrinology

ea0044p61 | Bone and Calcium | SFEBES2016

FGF23, iron and vitamin D metabolism in chronic kidney disease

Piec Isabelle , Chipchase Allison , Nicholls Holly , Tang Jonathan , Washbourne Christopher , Fraser William D

Introduction: In CKD, net effects of declining kidney function and increasing FGF23 (and PTH) concentrations on vitamin D catabolism and iron metabolism are not clear.Objectives: Compare the Biomedica to the ImmutopicsÂ’ immunoassay for measurement of cFGF23. Determine the relationship between iron status; vitamin D and intact FGF23 (iFGF23) and c-terminal (cFGF23) concentrations in blood.Method: Samples from routine care and a...

ea0044p72 | Clinical biochemistry | SFEBES2016

Changes in serum 25-hydroxyvitamin D, 24,25-dihydroxyvitamin D and 1,25-dihydroxyvitamin D in response to three vitamin D3 supplementation regimens

Tang Jonathan , Nicholls Holly , Dutton John , Piec Isabelle , Washbourne Christopher , Saleh Lanja , Novak A , Close Graeme , Macdonald Helen , Fraser William

Background: 25-hydroxyvitamin D (25(OH)D) is metabolised into two forms of metabolites: 1,25-dihydroxyvitamin D (1,25(OH)2D) by the actions of 1α hydroxylase, and 24,25-dihydroxyvitamin D (24,25(OH)2D) by 24-hydroxylase. Studies suggest the production of 1,25(OH)2D is 24,25(OH)2D dependent. Genetic mutations of CYP24A1 gene resulting in reduced or total loss of 24-hydroxylase function are associated with hypercalcaemic condition...