Endocrine Abstracts

A 27 year old lady presented in 2016 with a 3 month history of intermittent headache and visual disturbance, 3.5 months post-partum. She had a past medical history of cluster headache; treated with verapamil and short courses of oral steroids (she had no recent steroid courses prior to presentation). She was found to have a partial right sixth nerve palsy but normal visual fields on Goldmann’s testing. She had biochemical evidence of secondary adrenal insufficiency (sodi...

Background: Cushing’s disease (CD) is rare, and standard treatment is trans-sphenoidal surgery (TSS). We previously reported a remission rate of 56% in patients undergoing TSS for CD from a microadenoma/normal pituitary on MR in our unit. Early post-operative hypocortisolaemia performs well at predicting durable remission early on. Post-operative day 1 cortisol of <55 nmol/l has a 100% sensitivity and <138 nmol/l 95% sensitivity at predicting remission. Since Octo...

Background: Pituitary abscess is rare but a serious intrasellar infection. It should be considered in the differential diagnosis of the sellar masses due to its high morbidity and mortality rates. Despite recent advances in radiological investigations, it remains a challenge to make a definitive diagnosis preoperatively [1]. We present a case of pituitary abscess who presented with pan hypopituitarism and central diabetes insipidus.Case presen...

Objective: Clinical management of pituitary cysts remains controversial, especially if asymptomatic. We retrospectively review clinical management and outcome of these patients undergoing long-term follow-up in our pituitary clinic.Methods: All patients with MRI-based diagnosis of pituitary cyst were included. Clinical presentation, cyst size and endocrinopathies (secondary adrenal, thyroid or gonadal deficiency) were compared between surgical and observ...

Objective: Standard Cushing’s disease (CD) treatment is trans-sphenoidal surgery (TSS). However, reported postoperative remission and relapse rates are variable. We have retrospectively analysed clinical outcomes of patients with CD undergoing TSS at our centre.Methods: Patients with CD currently under our long-term endocrine care were included. Diagnosis of CD was made following standard biochemical and radiological investigations. Post-operative r...