Searchable abstracts of presentations at key conferences in endocrinology

ea0037gp.08.03 | Reproduction: Male and endocrine disruptors | ECE2015

Infertile men have frequently Leydig cell dysfunction: study on hypogonadism, vitamin D and bone mass in 5177 subjects

Ferlin Alberto , Garolla Andrea , Selice Riccardo , Caretta Nicola , Pizzol Damiano , Foresta Carlo

Spermatogenic disruption is normally recognized by low sperm count and FSH levels. However, Leydig cell impairment is also frequent in subjects with primary testicular damage, as evidenced for example by reduced INSL3 and 25(OH)-vitamin D levels. The latter is caused by reduced expression of CYP2R1, a major enzyme involved in 25-hydroxylation of cholecalciferol. Furthermore, testosterone (T) production by the Leydig cells might be also impaired in men with primary spermatogeni...

ea0037gp.10.08 | Calcium, Vitamin D and Bone | ECE2015

Role of vitamin D levels and vitamin D supplementation on bone mineral density in Klinefelter syndrome

Ferlin Alberto , Selice Riccardo , Di Mambro Antonella , Ghezzi Marco , Caretta Nicola , Foresta Carlo

Introduction: Decreased bone mineral density (BMD) in Klinefelter syndrome (KS) is frequent and it has been traditionally related to low testosterone levels. However, low BMD can be observed also in patients with normal testosterone levels and testosterone replacement therapy does not necessarily increase bone mass in these patients. Nothing is known about vitamin D levels and supplementation in KS. In this study we determine vitamin D status and bone mass in KS subjects and c...

ea0037ep221 | Reproduction, endocrine disruptors and signalling | ECE2015

Copy number variations in the X chromosome of Klinefelter syndrome

Ferlin Alberto , Rocca Maria Santa , Pecile Vanna , Selice Riccardo , Caretta Nicola , Foresta Carlo

Introduction: Klinefelter syndrome (KS) is characterised by the presence of at least one extra X chromosome and represents the most common chromosomal aberration in men. Apart from infertility, the clinical spectrum of KS is variable and often not directly related to hypogonadism, whose expression is also not unpredictable. Several genetic mechanisms may explain the clinical features and variability of the phenotype in KS. In particular, gene-dosage effects and the parental or...

ea0081ep913 | Reproductive and Developmental Endocrinology | ECE2022

Color-doppler ultrasound predicts hypothalamic-pituitary-testicular axis function in infertile patients

Grande Giuseppe , Palego Pierfrancesco , Canossa Andrea , Caretta Nicola , Nisio Andrea Di , Corona Giovanni , Ferlin Alberto , Foresta Carlo , Garolla Andrea

Scrotal color-doppler ultrasonography (sCDUS) and transrectal ultrasonography (trCDUS) provide crucial information about the clinical status of testes and male accessory glands. However, the US evaluation of the infertile male is still often considered as a second level diagnostic tool. To analyze the role of ultrasound in male infertility, in order to predict hypothalamic-pituitary-testicular axis function, 1120 records from infertile men were retrospectively evaluated (from ...