Searchable abstracts of presentations at key conferences in endocrinology

ea0067gp29 | Poster Presentations | EYES2019

Relapsed acromegaly after 3 years of remission following pituitary apoplexy

Dobre Ramona , Niculescu Dan Alexandru , Poiana Catalina

Background: Pituitary apoplexy is a rare clinical syndrome manifested by rapid enlargement of a pituitary mass. When apoplexy occurs in functioning adenomas, it may result in spontaneous remission with or without associated hypopituitarism. Cases of recurrence in such patients are reported in literature.Case description: We present a case of a 44 years old male, overweight and dyslipidemic that presented to our clinic in 2016 and was diagnosed with acrom...

ea0063p480 | Calcium and Bone 2 | ECE2019

Seasonal variation of osteoporotic hip fracture admitted in trauma centers in Bucharest

Dobre Ramona , Niculescu Dan Alexandru , Poiana Catalina

Hip fracture remains the most important clinical manifestation of osteoporosis, with many studies demonstrating a relationship between seasons and the incidence and mortality after hip fracture.Objective: We aimed to identify a seasonal variation (four seasons) in incidence of osteoporotic hip fracture admitted in trauma centers in Bucharest.Materials and methods: We observed the seasonal variation of 1176 patients, mean age 78.19+...

ea0032p66 | Adrenal Medulla | ECE2013

Plasma free metanephrine and normetanephrine in chronic kidney disease patients

Niculescu Dan , Ismail Gener , Poiana Catalina

Chronic kidney disease (CKD), with or without dialysis, often prompt biochemical tests for pheochromocytoma diagnosis due to high blood pressure, hemodynamic instability or association with certain genetic syndromes. Our objective was to assess plasma free metanephrine and normetanephrine in CKD disease patients, with or without dialysis.Methods: Plasma free metanephrine and normetanephrine were measured by an enzyme-linked immunosorbent assay in 42 pati...

ea0081p227 | Thyroid | ECE2022

Thyrotoxicosis-associated anemia at baseline and after methimazole treatment

Naglabeala Laura , Alexandru Niculescu Dan , Vladescu Anda , Poiana Catalina

Background: Overt newly diagnosed hyperthyroidism is frequently associated with mild anemia. However, there are limited data on long term evolution under methimazole treatment. Our aim was to study the baseline characteristics and evolution of anemia in the hyperthyroidism setting.Methods: We retrospectively assessed 58 consecutive patients [46 (79.3%) women] presenting with newly diagnosed overt thyrotoxicosis (43 Graves disease, 9 toxic nodular goiters...

ea0041ep1066 | Thyroid (non-cancer) | ECE2016

Hypertrophic Hashimoto’s thyroiditis mimicking thyroid lymphoma

Alexandru Niculescu Dan , Iorgulescu Radu , Dumitrascu Anda , Poiana Catalina

Introduction: Hashimoto’s thyroiditis (HT) is a well known risk factor for thyroid lymphoma. A rapidly enlarging goiter accompanied by lymph nodes pressure on surrounding structures usually suggest the development of thyroid lymphoma.Case report: An 85 years old hypertensive women presented for a massive goiter extending from the lower jaw to clavicle which increased in size for the last 5 months. She also complained of dysphagia, hoarseness and sho...

ea0070ep437 | Thyroid | ECE2020

The learning curve of a new thyroid fine-needle aspiration facility

Alexandru Niculescu Dan , Terzea Dana , Deacu Laura , Poiana Catalina

Fine-needle aspiration (FNA) is the best available technique for preoperative diagnosis of malignancy in thyroid nodules. Although its efficiency has been well described, the learning curve is underreported. We aimed to describe the learning curve of a new FNA facility (endocrinologist/pathologist) in a university based hospital.Methods: In February 2018 a new FNA facility was formed in our hospital comprising an endocrinologist with high experience in t...

ea0022p631 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Correlation between GH and FSH in the cerebrospinal fluid and sleep respiratory events

Capatina Cristina , Niculescu Dan , Caragheorgheopol Andra , Coculescu Mihail

Introduction: There are high levels of anterior pituitary hormones in the cerebrospinal fluid (CSF), i.e. beyond the blood–brain barrier, in many patients with pituitary tumors.Aim: To assess the influence of CSF pituitary hormones on brain functions reflected by sleep architecture and sleep apnea.Method: Twenty-nine patients (17 women, 12 men) with pituitary adenomas (20 acromegaly, 5 nonfunctioning pituitary adenomas, 4 prol...

ea0020oc4.2 | Acromegaly/IGF1/Type 2 Diabetes | ECE2009

Both insulin resistance and insulin secretion are involved in the pre-diabetes of acromegaly

Niculescu Dan , Purice Mariana , Lichiardopol Radu , Coculescu Mihail

In acromegalic patients growth hormone (GH) excess induces insulin resistance but whether this is sufficient, in the face of normal insulin secretion, for pre-diabetes (impaired fasting glucose (IFG) and impaired glucose tolerance (IGT)) to occur is a matter of debate.Aim: To assess the relative role of insulin resistance and insulin secretion in the pre-diabetes of acromegaly.Methods: One hundred and twenty-four patients with acro...

ea0014p83 | (1) | ECE2007

Insulin resistance and insulin secretion in non-diabetic acromegalic patients

Niculescu Dan , Purice Mariana , Lichiardopol Radu , Coculescu Mihail

Aim: To set up, in acromegaly without diabetes mellitus, a correlation between the disease activity in GH-secreting adenoma (AA) - assessed by minimum GH serum level during an oral glucose tolerance test (OGTT) - and severity of insulin resistance (IR), assessed by HOMA-IR index.Methods: 75 out of 88 consecutive patients with acromegaly hospitalized in our department were included in this study. 13 patients proved to have diabetes mellitus and were exclu...

ea0056p634 | Clinical case reports - Thyroid/Others | ECE2018

When it is the time of prophylactic thyroidectomy to children with medullary thyroid cancer with RET proto-oncogene Cys634Trp mutation in a family with multiple endocrine neoplasia type 2A

Galesanu Corina , Niculescu Dan , Apostu Luminita , Romeo Galesanu Mihail

Background: Almost all patients with Multiple Endocrine Neoplasia, type 2A (MEN 2A) have MTC. C-cell hyperplasia develops early in life and can be viewed as the precursor lesion for MTC. Children with MEN2A who have a total early thyroidectomy have an excellent chance of remaining disease-free.Objectives: To follow-up the children with RET mutation in a family with MEN2A.Methods: We report a family with MEN2A in which the first pat...