Searchable abstracts of presentations at key conferences in endocrinology

ea0011p706 | Reproduction | ECE2006

Functional characterization of the follicle-stimulating hormone receptor core promoter: applying a comparative approach among primates

Brune M , Kostova E , Nieschlag E , Gromoll J

Follicle-stimulating hormone (FSH) is essential for primate reproduction, acting via the FSH-receptor (FSHR) which is expressed in Sertoli and granulosa cells only. Despite its highly specific expression pattern, knowledge of the FSHR promoter and transcriptional regulation is still very limited. To gain insights into the regulatory elements controlling FSHR expression we characterized the core promoter activity of all important primate lineages including human. We isolated DN...

ea0010s2 | Clinical Endocrinology Trust Historical Lecture | SFE2005

The history of testosterone

Nieschlag E

2005 marks the 100th anniversary of the creation of the term hormone by Ernest Starling. Although its biological effects were known since antiquity, the name testosterone (T) was coined only in 1935, when Ernest Laqueur isolated it from bull testes. The road to this isolation was long: John Hunter had transplanted testes into capons in 1786 and Adolph Berthold postulated internal secretion from his testicular transplantation experiments in 1849. Following his obs...

ea0010s2biog | Clinical Endocrinology Trust Historical Lecture | SFE2005

Clinical Endocrinology Trust Historical Lecture

Nieschlag E

E Nieschlag, Institute of Reproductive Medicine of the University, Muenster, Germany AbstractEberhard Nieschlag studied medicine at the Universities of Bonnand Munich and biochemistry at University College London. He went on to specialize in internal medicine and endocrinology at the University Hospitals of Mainz and Düsseldorf. He has also conducted research at the MRC Clinical Research Unit for Reproductive En...

ea0011p177 | Clinical practise and governance | ECE2006

Symptom-specific thresholds for testosterone deficiency modulate complaints and metabolic risk in 434 aging male patients

Zitzmann M , Faber S , Nieschlag E

Objective: The structure of psychological and somatic complaints of aging male patients in relation to sex hormone patterns and metabolism has not been fully elucidated, especially in regard to late-onset hypogonadism.Methods: We investigated the nature of complaints in 434 consecutive patients aged 50–86 years attending our andrology unit and their association with physical characteristics, life style habits and sex hormone levels.<p class="abs...

ea0011p178 | Clinical practise and governance | ECE2006

Longterm experience of more than 8 years with a novel formulation of testosterone undecanoate (Nebido) in substitution therapy of hypogonadal men

Zitzmann M , Saad F , Nieschlag E

Objective: A reliable form of androgen substitution therapy in terms of favorable kinetics and tolerance as well as effective restoration of androgenicity is paramount in hypogonadal men. A feasible modality is the intramuscular injection of the long-acting ester testosterone undecanoate (TU).Design: We report data from 22 patients (15 with primary and 7 with secondary hypogonadism) aged 30 to 65 years (mean 43.8±8 years) who received injections of ...

ea0008s17 | Consequences of a lack of androgens | SFE2004


Nieschlag E , Gromoll J , Zitzmann M

Testosterone is the hormone that turns males into men and a lack of testosterone, whether of primary or secondary origin, causes hypogonadism characterized by lack of pubertal development or loss of maleness. It was generally assumed that in a man with a normal androgen receptor (AR) androgenicity is regulated by testosterone serum concentrations, slightly modified by SHBG. Only recently it became evident that variations in the AR gene influence testosterone action. Modulation...

ea0011p645 | Reproduction | ECE2006

Spermatogenesis in autologous testicular transplants in the non-human primate Callithrix jacchus

Luetjens CM , Schlatt S , Nieschlag E , Simoni M , Wistuba J

Immature testicular tissue was successfully xenografted in several species but did not lead to spermatogenesis with tissue obtained from the non-human primate Callithrix jacchus. Previous data indicate that the microenvironment provided by the mouse host might cause this failure. We conducted an in vivo study performing autologous ectopic transplantation of testicular fragments in newborn anaesthetised marmoset monkeys and compared transplanted animals to sham op...

ea0011p647 | Reproduction | ECE2006

Dependence of semen characteristics on abstinence time, testicular volume and hormones

Tüttelmann F , Luetjens CM , Cooper TG , Simoni M , Nieschlag E

Evaluation of male fertility, based on semen analysis, is complicated by high variability of semen parameters and the lack of evidence-based reference values. The standards are currently set by the WHO laboratory handbook (1999). We investigated whether taking into account abstinence time and testicular volume would reduce variation in sperm concentration / count and thereby consolidate the underlying principles of spermatogenesis.The database of our Ins...