Searchable abstracts of presentations at key conferences in endocrinology

ea0021p328 | Reproduction | SFEBES2009

Twice-weekly administration of kisspeptin leads to long-term stimulation of reproductive hormone release in infertile women with hypothalamic amenorrhoea

Jayasena Channa N , Nijher Gurjinder M K , Abbara Ali , Murphy Kevin G , Lim Adrian , Patel Daksha , Mehta Amrish , Todd Catriona , Ramachandran Radha , Donaldson Mandy , Trew Geoffrey , Ghatei Mohammad A , Bloom Stephen R , Dhillo Waljit S

Background: Hypothalamic amenorrhoea (HA) accounts for over 30% of cases of amenorrhoea in women of reproductive age. Current treatments have limited success rates and side effects. We have recently shown that a single injection of the novel hormone kisspeptin potently stimulates reproductive hormone release in women with HA. However, twice-daily kisspeptin administration to women with HA, results in tachyphylaxis due to desensitisation of the kisspeptin receptor. This suggest...