Searchable abstracts of presentations at key conferences in endocrinology

ea0056gp255 | Thyroid non cancer - Autoimmune Thyroid disease/pregnancy | ECE2018

MicroRNA-4443 causes CD4+T cells dysfunction by targeting TRAF4 in Graves’ disease

Qi Yicheng , Ning Guang , Wang Shu

Context: Aberrant CD4+T cell function plays a critical role in the process of Graves’ disease (GD). MicroRNAs (miRNAs) are important regulators of T cell activation, proliferation and cytokine production. However, the contribution of miRNAs to CD4+T cell dysfunction in GD remains unclear.Objective: To investigate how certain miRNA causes aberrant CD4+T cell function in GD patients.Methods: We compared the expression pattern of...

ea0035p491 | Diabetes therapy | ECE2014

The favourable effects of autologous hematopoietic stem cell transplantation on the immune system in patients with type 1 diabetes

Li Li , Gu Weiqiong , Ye Lei , Yang Minglan , Wan Bin , Hong Jie , Wang Weiqing , Ning Guang

Objective: Autologous hematopoietic stem cell transplantation (AHSCT) is a promising treatment to reverse type 1 diabetes (T1D) in patients with significantly improved β-cell function. This study was designed to investigate the potential immunological mechanisms involved.Design and methods: 18 newly-diagnosed T1D were divided into two groups, the AHSCT group and the insulin therapy group. Blood mononuclear cells (PBMCs) of the patients at the baseli...

ea0035p387 | Diabetes (epidemiology, pathophysiology) | ECE2014

The HLA-A*33 haplotype enhances the risk of type 1 diabetesin ndividuals with HLA-DR3+ or DR9+ haplotype

Zhang Juanjuan , Gu Weiqiong , Wang Bokai , Gao Jie , Li Li , Cui Bin , Hong Jie , Wang Weiqing , Ning Guang

Background: To investigate the typing for HLA-I in Chinese patients with type 1 diabetes (T1D) as a complement screening for HLA-II.Methods: A total of 212 T1D patients and 200 healthy controls were enrolled. The genetic polymorphisms of HLA-I and II were examined with a high-resolution polymerase chain reaction-sequence-based typing method.Results: The novel haplotype, A*33:03-B*58:01-C*03:02(A33), was a...