Searchable abstracts of presentations at key conferences in endocrinology

ea0090p710 | Pituitary and Neuroendocrinology | ECE2023

Chordomas of the parasellar region: description of 4 cases of a rare disease

Cosme Ines , Nobre Ema , Joao Bugalho Maria

Background: Chordomas are rare, invasive and slow growing bone tumours with different locations. Parasellar chordomas are even more rare and the initial manifestations include visual and/or neurological symptoms. In addition, endocrine dysfunction may be present. We describe 4 cases of parasellar chordomas.Clinical cases: 1) Female, 55-years-old, reported headache associated with restriction of left eye movement for the past 3 months. Brain magnetic reso...

ea0090ep190 | Calcium and Bone | ECE2023

Denosumab in the treatment of fracturary osteoporosis: the double effect on bone and glycemic metabolism

Cosme Ines , Nobre Ema , Barbosa Ana Paula

Background: Denosumab (Dmab) is a human monoclonal antibody with an anti-reabsorptive bone effect, used in osteoporosis treatment. It is also suggested that Dmab may improve glucose tolerance through the reduction of hepatic insulin resistance. Some studies have suggested that insulin sensitivity and glycemia can influence bone metabolism.Aims: To evaluate the relationship between bone turnover markers (BTM) and insulin resistance and glycemia in fractur...

ea0032p556 | Endocrine tumours and neoplasia | ECE2013

Acromegaly, primary hyperparathyroidism and meningioma – an unsual association in an asymptomatic patient with MEN1 syndrome

Ferreira Florbela , Nobre Ema , Wessling Ana , Carmo Isabel

Introduction: MEN1 is inherited as an autosomal dominant trait, with a prevalence of 2–20/100 000 in the general population. It is characterized by tumors envolving the parathyroid glands, the endocrine pancreas and the pituitary. Other tumors are more rarely associated: adrenal adenomas, carcinoid tumors, pheocromocytomas, angiofibromas, lipomas, collagenomas and meningiomas. The presence of two or more of MEN1 associated tumors is diagnostic of the syndrome.<p class...

ea0081ep752 | Pituitary and Neuroendocrinology | ECE2022

Clinical presentation of non-functioning pituitary tumors: the experience at a tertiary care hospital in Portugal

Ines Alexandre Maria , Gomes Ana , Nobre Ema Lacerda , Marques Pedro , Bugalho Maria Joao

Introduction: Clinically non-functioning pituitary tumors (NFPTs) lack clinical or biochemical evidence of pituitary hormone excess. Their clinical presentation is heterogeneous, including mass effect-related symptoms and/or hypopituitarism, or even no symptoms in incidentally-detected NFPTs. We aimed to evaluate the clinical presentation spectrum of NFPTs in a cohort of patients managed at our hospital.Methods: Clinical, demographic, biochemical and ima...

ea0063p1177 | Thyroid 3 | ECE2019

Single thyroid amyloidosis: a case report

Osorio Ana Sofia , Barbosa David , Nobre Ema , Marques Tiago , Cantiga Paulo

Introduction: Thyroid amyloidosis is defined as amyloid protein and fat deposition within the thyroid gland. It is classified as either primary (idiopathic) or secondary to inflammatory/chronic disease. Albeit deposition of amyloid protein in thyroid tissue is frequent, amyloidosis affecting exclusively the thyroid gland without evidence of other organs involved is extremely rare. We report a clinical case of a patient who underwent lobectomy due to a toxic adenoma, whose hist...

ea0049gp237 | Thyroid Cancer &amp; Thyroid Case Reports | ECE2017

Thyrotoxic Periodic Paralysis due to Graves’ disease: a mandatory differential diagnosis in Asian patients presenting with paralysis and hypokalemia

Barbosa David , Faria Carolina , Osorio Ana Sofia , Nobre Ema , Vilas Ana Paula , Bugalho Maria Joao

Introduction: Thyrotoxic periodic paralysis (TPP) is a potentially life-threatening complication of hyperthyroidism that is underdiagnosed and frequently missed. It is relatively common in Asian men with Graves’ disease. TPP attacks are frequently associated with hypokalemia.Case presentation: We describe a 26-year-old Asian male with an unremarkable past medical history who was admitted following sudden onset of flaccid paralysis of the lower extre...

ea0049gp239 | Thyroid Cancer &amp; Thyroid Case Reports | ECE2017

Renal cell carcinoma metastasis to thyroid tumor: a case report

Faria Carolina , Barbosa David , Osorio Ana Sofia , Nobre Ema , Bugalho Maria Joao

Introduction: Subacute thyroiditis (SAT) association with papillary thyroid carcinoma (PTC) has been rarely reported in the literature. Metastatic neoplasms to the thyroid are rare in clinical practice. Renal cell carcinomas (RCC) are the most frequent site of origin of thyroid metastases (12 to 34%). Tumor-to-tumor metastases, in which a thyroid neoplasm is the recipient of a metastasis, are exceedingly rare. Tuberous sclerosis (TS) is associated with several renal manifestat...

ea0049ep95 | Adrenal medulla | ECE2017

Biochemical testing for pheochromocytoma

Faria Carolina , Barbosa David , Osorio Ana Sofia , Nobre Ema , Sampaio Joaquim , Bugalho Maria Joao

Introduction: Biochemical testing for Paraganglioma/Pheochromocytoma (PGL/PHEO) is recommended in patients with classical symptoms, in those harbouring an adrenal incidentaloma and in patients who have a hereditary risk for developing a PGL/PHEO. Measurements of plasma free metanephrines and/or urinary fractionated metanephrines provide a highly sensitive test for diagnosis but false-positive results remain a problem.Aim: Comparative analysis of plasma a...

ea0049ep320 | Clinical case reports - Thyroid/Others | ECE2017

Parathyroid nodular hyperplasia: when imaging exams fail

Osorio Ana Sofia , Rocha Jose , Faria Carolina , Barbosa David , Nobre Ema , Bugalho Maria Joao

Introduction: Parathyroid hyperplasia is the second cause of primary hyperparathyroidism (PH), representing 15–20% of all cases. The scintigraphy with Tc-99m-Sestamibi is a preoperative exam used to identify parathyroid adenomas or hyperplasia. It has a sensibility of 50–90%, which increases with larger parathyroid size. The neck ultrasonography (US) has also an important role detecting parathyroid enlarged glands with 70% sensibility. We report a case of parathyroid...

ea0049ep1037 | Pituitary - Clinical | ECE2017

Pituitary Stalk Hemangioblastoma: a case report and review of the literature

Barbosa David , Faria Carolina , Osorio Ana Sofia , Nobre Ema , Bugalho Maria Joao

Introduction: Hemangioblastomas (HBL) in the pituitary stalk are extremely rare. Most pituitary stalk HBL reported in the literature were associated with von Hippel–Lindau (VHL) disease.Case report: We report the case of a 34-year-old female patient with VHL disease diagnosed at the age of 18 with multiple complications (bilateral retinal and cerebellum HBL, renal cell carcinoma). Brain magnetic resonance imaging (MRI) demonstrated an hypointense su...