Searchable abstracts of presentations at key conferences in endocrinology

ea0038p143 | Growth and development | SFEBES2015

Vitamin D promotes myogenic differentiation and induces an antifibrotic phenotype in primary cultures of skeletal muscle derived satellite cells and fibroblasts

Daoud Amanda , Kim Irene , Norris Keith , Ferrini Monica , Artaza Jorge

Purpose of study: Skeletal muscle wasting is a serious public health problem associated with aging, chronic kidney disease, and AIDS. Vitamin D (VD) is most widely recognised for its regulation of calcium and phosphate homeostasis in relation to bone development and maintenance and for its synergistic effects on target organs such as PTH glands. Recently, it has been shown to improve muscle performance and reduce falls in VD deficient older adults. However, little is known of ...

ea0038p60 | Clinical practice/governance and case reports | SFEBES2015

Sodium–glucose co-transporter 2 inhibitor associated normoglycaemic ketoacidosis

Bobart Shane , Gleason Benjamin , Schroeder Jonathan , Martinez Nydia , Norris Keith , Williams Sandra

Sodium–glucose co-transporter 2 (SGLT2)-inhibitors represent a new class of drugs that inhibit glucose re-uptake in the proximal renal tubule resulting in glycosuria, with concomitant weight loss and improved glycaemic control in patients with type 2 diabetes mellitus (T2DM). Since becoming available, SGLT2 inhibitors have been implicated in over 20 reported cases of diabetic ketoacidosis or ketosis. In many cases there was an antecedent period of decreased oral intake, a...