Searchable abstracts of presentations at key conferences in endocrinology

ea0084ps3-14-131 | Thyroid Cancer CLINICAL 2 | ETA2022

Somatic BRAF V600E mutation in a patient with medullary thyroid carcinoma

Vaclavikova Eliska , Pekova Barbora , Sykorova Vlasta , Moravcova Jitka , Mastnikova Karolina , Novak Zdenek , Drozenova Jana , Chovanec Martin , Vcelak Josef , Bendlova Bela

Introduction: Medullary thyroid carcinoma (MTC) is a calcitonin-producing tumor that predominantly occurs in a sporadic form (75%) and less commonly in an inherited form. Besides activating germline mutations of the RET proto-oncogene in hereditary syndromes of MEN2, somatic RET mutations are detectable in about 50% of sporadic MTC. Further, also RAS mutations have been discovered in 30% of RET-negative tumor tissues. Other genetic alteratio...

ea0081ep1025 | Thyroid | ECE2022

Routine molecular testing of fine needle aspiration biopsies of thyroid nodules

Sykorova Vlasta , Moravcova Jitka , Vaclavikova Eliska , Pekova Barbora , Mastnikova Karolina , Vcelak Josef , Novak Zdenek , Pacesova Petra , Grimmichova Tereza , Jiskra Jan , Bendlova Bela

Objectives: Fine needle aspiration biopsy (FNAB) together with ultrasonography is a necessary tool for diagnosis and follow up of thyroid nodules. Molecular testing is increasingly used mainly for indeterminate categories of the Bethesda System for Reporting Thyroid Cytopathology revised in 2017. Our aim was to introduce a routine molecular analysis of the main genetic causes of thyroid cancer.Methods: Since 2017 we have analyzed 1171 samples of patients...

ea0073aep739 | Thyroid | ECE2021

Thyroid cancer detection in routine clinical setting-pilot study

Grimmichova Tereza , Petra Pačesová , Hill Martin , Vaclavikova Eliska , Pekova Barbora , Moravcova Jitka , Vrbikova Jana , Novak Zdenek , Sykorova Vlasta

BackgroundMost thyroid nodules are benign, but therefore it is crucial to correctly stratify the malignancy risk of nodules to avoid unnecessary invasive procedures and/or surgery, but and still identify aggressive tumors. The aim of our study was to address the potential for improvement of malignancy detection in routine clinical setting using clinical examination, risk stratification of thyroid nodules on ultrasound using the American College of Radiol...

ea0084ps3-15-138 | Thyroid Cancer Diagnosis & Treatment | ETA2022

Routine molecular analysis of fine-needle aspiration biopsies of thyroid nodules

Sykorova Vlasta , Moravcova Jitka , Vaclavikova Eliska , Pekova Barbora , Mastnikova Karolina , Vcelak Josef , Novak Zdenek , Pacesova Petra , Grimmichova Tereza , Jiskra Jan , Bendlova Bela

Objectives: Molecular testing of fine-needle aspiration biopsy (FNAB) samples is increasingly used mainly for indeterminate categories of the Bethesda System for Reporting Thyroid Cytopathology. Our aim was to introduce a routine molecular analysis of the main genetic causes of thyroid cancer.Methods: In total, 1354 FNAB samples of thyroid nodules were analyzed. Testing procedures mainly in samples evaluated as Bethesda categories III and above were grad...