Searchable abstracts of presentations at key conferences in endocrinology

ea0081p265 | Adrenal and Cardiovascular Endocrinology | ECE2022

Adrenergic crisis after SARS-COV-2 infection in a patient affected by pheochromocytoma

Novizio Roberto , Emanuele Rizzo Gaetano , Paragliola Rosa Maria , Maggio Ettore , Locantore Pietro , Maria Corsello Salvatore

Background: SARS-CoV-2 infection is characterized by aspecific symptoms (e.g., fever, cough) and can be complicated by viral pneumonia and many other manifestations can occur. Endocrinological complications have also been described. Pheochromocytomas are rare tumors located in the adrenal medulla, causing symptoms due to catecholamines overproduction and abrupt release. Catecholamines release can be continuous or intermittent and there can be several triggers including stress,...

ea0081p229 | Thyroid | ECE2022

An innovative synthetic support for cytological and immunocytochemical assessment in cytologically indeterminate thyroid nodules. Feasibility study

Taccogna Silvia , Novizio Roberto , D'angelo Martina , Turrini Luca , Persichetti Agnese , Pontecorvi Alfredo , Papini Enrico , Guglielmi Rinaldo

Background: Fine needle aspiration (FNA) is the diagnostic procedure of choice in the evaluation of thyroid nodules. Nodules with indeterminate cytological categories, Tir3A and Tir3B according to Italian cytological classification, pose diagnostic challenges in clinical practice and are frequently submitted to diagnostic surgery. CytoFoam Core (CF) (Diapath, Martinengo, Italy) uses an absorbent foam device inserted into the needle hub to collect the cytological sample aspirat...

ea0081ep953 | Thyroid | ECE2022

Risk of malignancy of indeterminate thyroid nodules: an Italian single-center cohort study

Cera Gianluca , Novizio Roberto , Corsello Andrea , Rossi Esther Diana , Locantore Pietro , Pontecorvi Alfredo

Background: In 2014 a new Italian classification system of thyroid cytology divided the indeterminate TIR3 category in two groups, TIR3A and TIR3B, aiming to reduce unnecessary thyroidectomies. The reported risk of malignancy is: TIR3A: <10%, suggesting follow-up and possible FNA repetition after 6 months, and TIR3B: 15-30%, recommending surgery.Objectives: We aimed to: evaluate the histological prevalence of malignancy in TIR3A and TIR3B nodules in ...

ea0075a12 | Adrenal gland | EYES2021

Evaluation of urinary free cortisol and late night salivary cortisol as diagnostic tools for Cushing’s Syndrome

Novizio Roberto , Locantore Pietro , Mura Chiara , Emanuele Rizzo Gaetano , Ramunno Vittoria , Maria Corsello Salvatore

Background: CushingÂ’s syndrome (CS) is characterized by inappropriate cortisol secretion and its diagnosis is still challenging for endocrinologist. Nevertheless, CS is a rare condition, making difficult to collect data and establish testsÂ’ diagnostic performances.Objectives: Assessing diagnostic performances of Urinary Free Cortisol (UFC) evaluated by liquid chromatography method coupled with tandem mass (LC-MS/MS) and Late Night Salivary Cort...

ea0075m13 | Metabolic Bone | EYES2021

Hypoparathyroidism after total thyroidectomy in a woman who underwent to bariatric surgery: A case report

Maggio Ettore , Veleno Miriam , Rossi Laura , Novizio Roberto , Emanuele Rizzo Gaetano , Morgante Cesare , Locantore Pietro

Background: Hypoparathyroidism (HypoPT) is characterized by low calcium and parathyroid hormone (PTH), often secondary to thyroid surgery. Treatment consists in activated vitamin D and calcium supplementation. Such treatment may be difficult in patients with malabsorption as calcium usually requires an acid environmental to dissolve, while calcitriol needs an intact intestine for a full absorption.Case report: A 36-year old woman had a history of sleeve ...

ea0081p313 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

Obesity and obesity-related diseases as a new clinical features in 3q27.3 microdeletion syndrome involving adipoq gene: a case study

De Brasi Davide , Novizio Vincenzo , Barba Livia , Scarano Elisabetta , Serino Domenico , Novizio Roberto , Della Monica Matteo , Petillo Roberta , Scavuzzo Francesco

Introduction: Adipose tissue is recognized as an important endocrine organ, secreting many endocrine factors. Adiponectin is the most abundant peptide released into circulation, encoded by ADIPOQ gene localized in chromosome 3q27.3. Adiponectin decreases intracellular ceramide, implicated in insulin resistance, inflammation and atherosclerosis. It stimulates fatty acid oxidation in skeletal muscle and inhibits glucose production in the liver. Hypo-adiponectinemia plays a centr...

ea0075p05 | Pituitary and neuroendocrinology | EYES2021

A rare case of gonadotroph adenoma in a young woman

Veleno Miriam , Maggio Ettore , Morgante Cesare , Novizio Roberto , Laura Leo Maria , Policola Caterina , Locantore Pietro , Pontecorvi Alfredo

Background: Functioning gonadotroph adenomas (GA) account for 20 to 25% of all pituitary adenomas. Clinical presentation consists in multiple ovarian follicles and cysts, higher estradiol level and endometrial hyperplasia. The treatment of choice is transphenoidal tumor resection.Case Presentation: A 40 year old woman presented with abdominal pain and menstrual cycle dysfunctions. Hormonal evaluation showed: FSH:13.8 mU/ml, estradiol:1549 pg/ml, PRL:81.7...

ea0075t08 | Thyroid | EYES2021

Antibody Interference in Thyroid Assays: a case report

Mura Chiara , Menotti Sara , Zelano Lorenzo , Novizio Roberto , Rossi Laura , Carrozza Cinzia , Locantore Pietro , Maria Corsello Salvatore

Background: Endogenous and exogenous factors may cause biochemical interferences with thyroid function immunoassays. Interference can be caused by many mechanisms including heterophilic antibodies, drugs and rheumatoid factors. Moreover, assay-specific interference has been described, such as antithyroid hormone antibodies resulting in falsely elevated or lowered concentrations depending on the assay.Case Presentation: We describe a case of a 38-years ol...