Endocrine Abstracts

Cardiovascular disease (CVD) is by far the most common complication of type 2 diabetes. Suffering from type 2 diabetes does not only significantly increase the risk of CVD but is also associated with poor survival, both acutely and in the long term, after a myocardial infarction (MI). In fact, total mortality from coronary artery disease (CAD) in subjects with type 2 diabetes without a previous MI is as high as that of non-diabetic individuals with a previous infarction. Regar...

Background: Conventional glucocorticoid replacement therapies result in unphysiological variation in plasma cortisol levels; concern has been raised regarding long-term metabolic consequences. Glucocorticoid replacement is technically feasible by continuous subcutaneous hydrocortisone infusion (CSHI), which can mimic the normal diurnal cortisol rhythm. The aim of this study was to compare insulin sensitivity in patients with Addison’s disease (AD) on CSHI vs three daily d...

Background: Conventional glucocorticoid replacement therapy in patients with Addison’s disease (AD) is unphysiological with possible adverse effects on mortality, morbidity and quality of life. Physiological amounts of glucocorticoids are required for normal GH production and release and a chronically raised cortisol level, suppresses the secretion of GH with possible metabolic and cardiovascular consequences. The diurnal cortisol profile can likely be restored by continu...