Searchable abstracts of presentations at key conferences in endocrinology

ea0022s21.1 | The cardiometabolic interface | ECE2010

Endothelial dysfunction in type 2 diabetes

Nystrom Thomas

Cardiovascular disease (CVD) is by far the most common complication of type 2 diabetes. Suffering from type 2 diabetes does not only significantly increase the risk of CVD but is also associated with poor survival, both acutely and in the long term, after a myocardial infarction (MI). In fact, total mortality from coronary artery disease (CAD) in subjects with type 2 diabetes without a previous MI is as high as that of non-diabetic individuals with a previous infarction. Regar...

ea0032p9 | Adrenal cortex | ECE2013

Insulin sensitivity in patients with Addison's disease: a randomised cross-over trial comparing conventional glucocorticoid replacement therapy with continuous subcutaneous hydrocortisone infusion therapy.

Bjornsdottir Sigridur , Nystrom Thomas , Isaksson Magnus , Oksnes Marianne , Husebye Eystein , Lovas Kristian , Kampe Olle , Hulting Anna Lena , Bensing Sophie

Background: Conventional glucocorticoid replacement therapies result in unphysiological variation in plasma cortisol levels; concern has been raised regarding long-term metabolic consequences. Glucocorticoid replacement is technically feasible by continuous subcutaneous hydrocortisone infusion (CSHI), which can mimic the normal diurnal cortisol rhythm. The aim of this study was to compare insulin sensitivity in patients with AddisonÂ’s disease (AD) on CSHI vs three daily d...

ea0035p33 | Adrenal cortex | ECE2014

Circadian cortisol and GH profiles in patients with Addison's disease: a comparison of continuous subcutaneous hydrocortisone infusion with conventional glucocorticoid replacement therapy

Oksnes Marianne , Bjornsdottir Sigridur , Isaksson Magnus , Methlie Paal , Nilsen Roy , Kampe Olle , Hulting Anna-Lena , Husebye Eystein , Lovas Kristian , Nystrom Thomas , Bensing Sophie

Background: Conventional glucocorticoid replacement therapy in patients with AddisonÂ’s disease (AD) is unphysiological with possible adverse effects on mortality, morbidity and quality of life. Physiological amounts of glucocorticoids are required for normal GH production and release and a chronically raised cortisol level, suppresses the secretion of GH with possible metabolic and cardiovascular consequences. The diurnal cortisol profile can likely be restored by continu...