Endocrine Abstracts

Aim: Obesity is associated with activation of mammalian target of rapamycin (mTOR)/ ribosomal S6 kinase (S6K) signaling pathway that promotes cardiac hypertrophy, insulin resistance, endothelial dysfunction and oxidative stress. Although activation of mTOR/S6K has a harmful effect, simultaneously it represents adaptive metabolic response that protects cells from excessive nutrient intake. Insulin like growth factor-1 (IGF1) exerts pleiotropic action on heart promoting vasorela...

IntroductionNon-alcoholic fatty liver disease (NAFLD) is a component of metabolic syndrome (MetS). Hence, it is frequently associated with type 2 diabetes mellitus (T2DM). The low-grade inflammation associated with NAFLD usually explained the changes in serum iron metabolism. This study aims to assess the link between liver steatosis severity and serum iron, ferritin, and transferrin levels.Material and methods<p class="abstext...

Introduction: Ectopic thyroid tissue is a rare developmental abnormality with the prevalence of 1 per 100.000–300.000 persons in the general population. It is most commonly detected in younger women and presented as lingual thyroid. Here we report a rare case of ectopic thyroid tissue in the left adrenal gland.Case report: A 29-year old female without previous medical history was incidentally diagnosed with left adrenal gland mass detected on routi...

Propylthiouracil (PTU) sometimes induces autoimmune syndromes, such as PTU–induced lupus or vasculitis. Here we present hands and feet vasculitis-like skin changes observed several days after PTU introduction in a patient who suffered from serious diffuse toxic goiter. Because of segmental distribution, normal liver function test, and no signs of clinical deterioration, it was decided to continue PTU management and observe the patient. Primarily maculopapular rash became ...

Introduction: A number of studies reported that almost every fifth patient with thalassemia hav e diabetes. Various factors could contribute to inadequate retrograde glycemic control in thalassemia patients co-existed with diabetes. According to published data, HbA1C seems to be an insufficient marker of the quality of diabetes control in thalassemia patients.Case report: We present a male 67 years old type 2 diabetes patient with disease history for 15 ...

Introduction: Polycystic ovary syndrome is the most frequent ovarian dysfunction during the reproductive period. Its presence significantly impacts on the final scores of various Quality-of-Life (QoL) questionnaires. This pilot study aims to analyze the impact of hirsutism (H), as the component of PCOS, on the scores of determined generic (General Health Questionnaire-12, GHQ12) and disease-specific questionnaires (Polycystic Ovary Syndrome Questionnaire, PCOSQ) in PCOS subjec...

IntroductionHyponatremia is frequently encountered in clinical practice. Euvolemic hyponatremia (Syndrome of Inadequate Antidiuresis, SIAD) represents diagnostic and management challenge regarding etiology unraveling, its gradual acute substitution, and later causal treatment.Case reportA 68-year-old woman was admitted to the Emergency unit with acute psychosis. On examination, there were no focal neurologica...

One of the main causes of protracted, severe hypocalcemia after parathyroidectomy is hungry bone syndrome (HBS). We report the case of a 40-year-old man who was first admitted to the Endocrinology department of Zemun Clinical Hospital (ZCH) in order to perform a workup for hypercalcemia. Further laboratory and imaging diagnostics indicated that a giant parathyroid adenoma, measuring approximately 6 cm in size, was the cause of the hypercalcaemia. An endocrine surgeon at the Cl...