Endocrine Abstracts

Ipilimumab is an anti-CTLA-4 monoclonal antibody licensed for metastatic melanoma.A 70-year-old female with metastatic malignant melanoma presented with anorexia, malaise and confusion two weeks after her fourth dose of Ipilimumab. She had a low serum sodium of 124 pmol/L on proton pump inhibitor and selective serotonin reuptake inhibitors, which were stopped and she was fluid restricted to 1.5 litres/day. Her urinary sodium wa...

Ipilimumab is an anti-CTLA-4 monoclonal antibody licensed for metastatic melanoma.A 70-year-old female with metastatic malignant melanoma presented with anorexia, malaise and confusion two weeks after her fourth dose of Ipilimumab. She had a low serum sodium of 124 pmol/L on proton pump inhibitor and selective serotonin reuptake inhibitors, which were stopped and she was fluid restricted to 1.5 litres/day. Her urinary sodium wa...

The prevalence of Metabolic Associated Steatotic Liver Disease (MASLD) is approximately 55% in patients with Type 2 diabetes (T2DM). The EASL-EASD-EASO guidelines recommend screening patients with T2DM for MASLD. Fibrosis-4 Index (FIB-4) is a simple tool used to screen for MASLD in T2DM. FIB-4 scores are characterised as; low (<1.3), moderate (1.3 – 2.67) or high risk (>2.67). The aim of the audit was to screen a consecutive number of patients attending the out-pa...

Rationale: The Aldosterone:Renin ratio (ARR) is commonly used for patients fulfilling screening criteria for primary hyperaldosteronism (PA), followed by confirmatory testing. Reference intervals for interpretation of the ARR vary in accordance with local population and assay 1. While ARR provides high sensitivity for PA, this is compromised by low specificity, further compounded by medication interference. However, additional variables may improve the specificity of ARR as a ...

Limited data are available on the effect of transsphenoidal surgery using the endoscopic method on pituitary function. In this preliminary report we retrospectively evaluated the frequency of pituitary failure and recovery in a population of patients who underwent this procedure over a 12 months period. 42 (21 women) consecutive adult patients were included. 29 patients had non-secretory pituitary neuroendocrine tumours, the rest had secretory tumours and other non-adenomatous...