Searchable abstracts of presentations at key conferences in endocrinology

ea0081oc12.2 | Oral Communications 12: Reproductive and Developmental Endocrinology | ECE2022

Genetic cause of POI are common, the case for next generation sequencing?

Vogt Elinor , Bratland Eirik , Husebye Eystein Sverre , Bjornsdottir Sigridur , Berland Siren , Oksnes Marianne

Context: Premature ovarian insufficiency (POI) affects approximately 1-3% of women. Clinical presentations are heterogeneous and the underlying etiologies remain unknown in the majority of cases.Objective/aim: To characterize presentations of POI and to evaluate the distribution of underlying etiologies in women with newly diagnosed POI of unknown cause.Design: Prospective study of 100 women with newly diagnosed POI. Autoimmunity w...

ea0049ep49 | Adrenal cortex (to include Cushing's) | ECE2017

The short Synacthen test revisited – reevaluation of the normal reference range using LCMSMS

Ueland Grethe AEstrom , Methlie Paal , Oksnes Marianne , Lovas Kristian , Thordarson Hrafnkell , Husebye Eystein

Background: The Synachten test is used to diagnose for adrenal insufficiency (AI) and non-classical congenital adrenal hyperplasia (CAH). The cut-off levels for s-cortisol and s-17-hydroxyprogesterone are derived from immunoassays that were not well standardized and are no longer in use. Introduction of liquid chromatography tandem mass spectrometry (LCMSMS) could resolve the lack of standardization of steroid hormone assays and enable increased diagnostic accuracy.<p clas...

ea0037ep41 | Adrenal cortex | ECE2015

Effect of stress-dosed hydrocortisone on physical capacity in patients with Addison's disease

Simunkova Katerina , Jovanovic Nevena , Oksnes Marianne , Lovas Kristian , Husebye Eystein Sverre

The current conventional glucocorticoid (GC) replacement therapy in primary adrenal insufficiency (Addison’s disease) and congenital adrenal hyperplasia (CAH) renders the cortisol levels unphysiological, resulting in very high levels alternating with almost undetectable levels of cortisol over the day. This reduces not merely the patient’s quality of life but increases the patient’s morbidity and mortality. The HPA axis is characterised by a dynamic circadian va...

ea0035p595 | Endocrine tumours and neoplasia | ECE2014

Preoperative octreotide therapy in acromegaly: associations between effects on glucose homeostasis and biochemical cure

Helseth Ragnhild , Carlsen Sven , Bollerslev Jens , Svartberg Johan , Oksnes Marianne , Skeie Svein , Fougner Stine L

Objective: In acromegaly, high GH/IGF1 levels are associated with abnormal glucose metabolism. Treatment with somatostatin analogues (SSAs) reduces the GH and IFG-1 levels. However, SSAs may worsen glucose homeostasis despite this, due to concomitant inhibition of insulin secretion. We studied the possible association between biochemical cure and glucose homeostasis in de novo patients with acromegaly.Design: Post hoc analysis from a ra...

ea0035p876 | Pituitary Clinical (<emphasis role="italic">Generously supported by IPSEN</emphasis>) | ECE2014

Preoperative octreotide treatment of acromegaly: long-term results of a randomized, controlled study

Fougner Stine Lyngvi , Bollerslev Jens , Svartberg Johan , Oksnes Marianne , Cooper John , Carlsen Sven M

Objective: Early postoperative results for the Preoperative Octreotide Treatment of Acromegaly (POTA) study has been published, and like later randomized studies we demonstrated a beneficial effect of presurgical treatment with somatostatin analogues (SSA) in GH-secreting macroadenomas when evaluated 3–4 months postoperatively. However, concerns about a potential lingering effect of SSA and thereby potential false positive results have been raised. The objective of this s...

ea0032p9 | Adrenal cortex | ECE2013

Insulin sensitivity in patients with Addison's disease: a randomised cross-over trial comparing conventional glucocorticoid replacement therapy with continuous subcutaneous hydrocortisone infusion therapy.

Bjornsdottir Sigridur , Nystrom Thomas , Isaksson Magnus , Oksnes Marianne , Husebye Eystein , Lovas Kristian , Kampe Olle , Hulting Anna Lena , Bensing Sophie

Background: Conventional glucocorticoid replacement therapies result in unphysiological variation in plasma cortisol levels; concern has been raised regarding long-term metabolic consequences. Glucocorticoid replacement is technically feasible by continuous subcutaneous hydrocortisone infusion (CSHI), which can mimic the normal diurnal cortisol rhythm. The aim of this study was to compare insulin sensitivity in patients with Addison’s disease (AD) on CSHI vs three daily d...

ea0077p139 | Adrenal and Cardiovascular | SFEBES2021

The ULTRADIAN consortium - Ambulatory in vivo micro dialysis in primary adrenal insufficiency, preliminary data

Russell Georgina , Upton Thomas , Zavala Eder , Methlie Paal , Simunkova Katerina , Berinder Katerina , Botusan Ileena , Vassiliadi Dimitria , Tsagarakis Stelios , Kampe Olle , Husebye Eystein , Lightman Stafford , Oksnes Marianne , Bensing Sophie

Patients on long term glucocorticoid replacement therapy have higher rates of morbidity and mortality. One causative factor may be non-physiological cortisol replacement. We have developed as part of the ULTRADIAN consortium ( the U-RHYTHM, an ambulatory bio-sampling device that can collect clinical samples using in-vivo microdialysis every 20 minutes over the 24hour day whilst individuals continue with their normal everyday activities....

ea0037ep1350 | Endocrine nursing | ECE2015

Continuous subcutaneous hydocortisone infusion replacement treatement in adrenal insufficiency – how to start the hydrocortisone infusion

Simunkova Katerina , Jovanovic Nevena , Rostrup Espen , Methlie Paal , Oksnes Marianne , Nilsen Roy Miodini , Henno Hanne , Tilseth Mira , Godang Kristin , Kovac Ana , Lovas Kristian , Husebye Eystein Sverre

Many patients with primary adrenal insufficiency (Addison’s disease) take extra doses of glucocorticoids before or during stressful events, but benefit has not been demonstrated. We aimed to test the effect of an extra dose of glucocorticoids on cardiorespiratory, hormonal and metabolic parameters in response to physical activity in a randomised placebo-controlled, 2-weeks cross-over, clinical trial ( NTC01847690). Ten women with Addison’s disease a...

ea0035p33 | Adrenal cortex | ECE2014

Circadian cortisol and GH profiles in patients with Addison's disease: a comparison of continuous subcutaneous hydrocortisone infusion with conventional glucocorticoid replacement therapy

Oksnes Marianne , Bjornsdottir Sigridur , Isaksson Magnus , Methlie Paal , Nilsen Roy , Kampe Olle , Hulting Anna-Lena , Husebye Eystein , Lovas Kristian , Nystrom Thomas , Bensing Sophie

Background: Conventional glucocorticoid replacement therapy in patients with Addison’s disease (AD) is unphysiological with possible adverse effects on mortality, morbidity and quality of life. Physiological amounts of glucocorticoids are required for normal GH production and release and a chronically raised cortisol level, suppresses the secretion of GH with possible metabolic and cardiovascular consequences. The diurnal cortisol profile can likely be restored by continu...

ea0077oc4.4 | Adrenal and Cardiovascular | SFEBES2021

24-hour dynamics of free tissue adrenal hormones: A description of healthy normal variation

Upton Thomas , Zavala Eder , Russell Georgina , Oksnes Marianne , Grytaas Marianne , Simunkova Katerina , Botusan Ileana , Berinder Katarina , Bensing Sophie , Vassiliadi Dimitra , Methlie Paal , Kampe Olle , Tsagarakis Stelios , Husebye Eystein , Lightman Stafford

Adrenal hormones possess both circadian and ultradian rhythms, making interpretation of single time point measurements difficult, particularly in the context of suspected endocrine disease. Attempting to capture either normal or pathological rhythms in detail by traditional measurement of blood is impractical and generally unfeasible. However, minimally invasive microdialysis sampling of free tissue hormones coupled with a portable fraction collector (U-RHYTHM), and a targeted...