Searchable abstracts of presentations at key conferences in endocrinology

ea0031p137 | Cytokines and growth factors | SFEBES2013

Genes for IGF2 and related IGF binding proteins are associated with longitudinal trends in BMI

Narayanan Ram Prakash , Fu Bo , Payton Antony , Donn Rachelle , Heald Adrian , Ollier William ER , Gibson Martin

High IGF2 has been associated with longitudinal weight loss. We wished to study associations of genes coding for IGF2 and for binding proteins that have preferential IGF2 affinity (IGFBP2, IGFBP5 and IGFBP6) in 991 Caucasian subjects from Salford with type 2 diabetes.Fifteen IGF2, four IGFBP2, eight IGFBP5 and one IGFBP6 SNPs were successfully genotyped. Longitudinal BMI data for the years 2002 to 2009 was obtained fro...