Searchable abstracts of presentations at key conferences in endocrinology

ea0056s11.2 | Novel aspects of Craniopharyngioma | ECE2018

Bariatric surgery as treatment in craniopharyngioma

Olsson Daniel S.

Patients with craniopharyngioma suffer from excess mortality and morbidity, especially patients with childhood onset of the disease. The impaired outcome in these patients is in part related to hypothalamic obesity, which is mainly caused by hypothalamic damage. The hypothalamic damage seems to result in autonomic nervous system dysfunction as well as leptin and insulin resistance. These factors negatively affect food intake, food satisfaction, metabolism and energy expenditur...

ea0041ep747 | Neuroendocrinology | ECE2016

Limited value of the standard 8-hour water deprivation test in the diagnostic work-up of patients with suspected diabetes insipidus

Trimpou Penelope , Olsson Daniel S. , Ragnarsson Oskar

Background: Diabetes insipidus (DI) is characterized by polyuria and consequently thirst and polydipsia. Excessive water intake can also cause polyuria, i.e. primary polydipsia. It is of utmost importance to differentiate between the two disorders since the treatment is different.Aims: To study the clinical value of the standard 8-hour as well as an extended water deprivation test in patients with polyuria and polydipsia.P...

ea0063gp48 | Acromegaly and GH | ECE2019

Prolonged diagnostic delay in acromegaly is associated with long-term morbidity and excess mortality: data from a nationwide study

Esposito Daniela , Ragnarsson Oskar , Johannsson Gudmundur , Olsson Daniel S

Background: Clinical features of acromegaly develop insidiously and the diagnosis is often delayed. However, diagnostic delay (DD) in acromegaly has not been systematically investigated. Our primary aim was to investigate DD in a nationwide cohort of patients with acromegaly. Secondary aim was to study the impact of DD on morbidity and mortality.Methods: Adult patients diagnosed with acromegaly between 2001 and 2013 were identified in the Swedish Nationa...

ea0063p1011 | Interdisciplinary Endocrinology 2 | ECE2019

The prevalence of oral glucocorticoid use in doses associated with risk of tertiary adrenal insufficiency

Einarsdottir Margret J , Trimpou Penelope , Olsson Daniel S , Johannsson Gudmundur , Ragnarsson Oskar

Objective: Patients who receive ≥5 mg prednisolone per day, for more than 2–3 weeks, are at risk of developing glucocorticoid (GC) induced adrenal insufficiency (tertiary adrenal insufficiency, 3° AI). The aim of this study was to a) determine the prevalence of GC use in doses that are associated with development of 3° AI, b) assess prescription pattern of short and long-term GC treatment in adults and children, and c) investigate the indication for the GC...

ea0037gp.20.01 | Pituitary – Hypopituitarism | ECE2015

Reduced mortality due to malignant neoplasms in patients receiving long-term GH replacement therapy – a Swedish study based on more than 4000 patient-years

Olsson Daniel S , Nilsson Anna G , Trimpou Penelope , Bengtsson Bengt-AEke , Andersson Eva , Johannsson Gudmundur

Patients with hypopituitarism and untreated growth hormone (GH) deficiency have excess mortality. GH replacement therapy (GHRT) has many beneficial effects, but its impact on mortality has not been proven and there are still safety concerns regarding the potential cancer risk. We have therefore studied the mortality in non-functioning pituitary adenoma (NFPA) patients with and without GHRT. Only patients with NFPA were studied in order to eliminate the influence of the aetiolo...

ea0070aep677 | Pituitary and Neuroendocrinology | ECE2020

Carpal tunnel syndrome is common in patients with undiagnosed acromegaly – a swedish nationwide study

Vouzouneraki Konstantina , Esposito Daniela , Mukka Sebastian , Granfeldt Daniel , Ragnarsson Oskar , Dahlqvist Per , Olsson Daniel S

Background: Carpal tunnel syndrome (CTS) is common in patients with acromegaly, with a reported prevalence of 19–64%. We have studied CTS in a large national cohort of patients with acromegaly, and the temporal relationship between the diagnosis of the two diseases.Methods: Retrospective nationwide cohort study including patients diagnosed with acromegaly in Sweden between 2005 and 2017. Patients with acromegaly were identified in the Swedish Natio...

ea0056gp2 | Acromegaly | ECE2018

Retinal vessel abnormalities in acromegaly

Fuchtbauer Laila , Olsson Daniel S , Norrman Lise-Lott , Bengtsson Bengt-AEke , Hellstrom Ann , Johannsson Gudmundur

Growth hormone (GH) and insulin like growth factor 1 (IGF-I) modulate and stimulate angiogenesis and endothelial function. Excess of GH, as in acromegaly, is associated with cardiovascular morbidity and mortality, which is reversible after normalization of IGF-I and GH. Diabetes mellitus (DM) is a common comorbidity in acromegaly, but the prevalence of diabetes retinopathy in patients with acromegaly is unknown. Also, the roles of GH and IGF-I in diabetes retinopathy are not f...

ea0073aep39 | Adrenal and Cardiovascular Endocrinology | ECE2021

Increasing incidence of primary aldosteronism – yet an underdiagnosed disorder

Gkaniatsa Eleftheria , Ekerstad Eva , Gavric Emanuela , Trimpou Penelope , Olsson Daniel S. , Johannsson Gudmundur , Ragnarsson Oskar

ContextPrimary aldosteronism (PA) is the most common cause of secondary hypertension. Yet, the incidence of PA in the population has not been studied.ObjectiveTo estimate the incidence of PA in western Sweden.Design and methodsPatients who had received a diagnostic code for PA between 1987 and 2016 were identified in the Swedish National Patient Registry. Assessme...

ea0081rc4.6 | Rapid Communications 4: Pituitary and Neuroendocrinology 1 | ECE2022

Impact of diabetes on morbidity and mortality in patients with acromegaly

Esposito Daniela , Olsson Daniel S , Franzen Stefan , Gudbjornsdottir Soffia , Miftaraj Mervete , Natman Jonatan , Svensson Ann-Marie , Johannsson Gudmundur

Background: Diabetes is an important risk factor for cardiovascular morbidity and mortality but its impact on outcome in acromegaly is unknown.Methods: This was a nationwide, observational, matched-cohort study. Adult patients with acromegaly due to a pituitary adenoma were identified in the Swedish National Patient Registry between 1987 and 2020 and those with coexistent type 2 diabetes in the National Diabetes Registry and Drug Registry. Overall mortal...

ea0041oc13.3 | Pituitary Clinical | ECE2016

Increased glucocorticoid replacement doses are associated with excess mortality in patients with non-functioning pituitary adenoma

Hammarstrand Casper , Hallen Tobias , Andersson Eva , Skoglund Thomas , Nilsson Anna G , Ragnarsson Oskar , Johannsson Gudmundur , Olsson Daniel S

Background: Patients with secondary adrenal insufficiency have an excess mortality. Data concerning the influence of the glucocorticoid replacement regime on mortality is sparse.Objective: To investigate if the total daily dose of glucocorticoid replacement has an effect on mortality in patients with non-functioning pituitary adenoma (NFPA).Method: Patients with NFPA treated for hypopituitarism in the western region of Sweden were ...