Searchable abstracts of presentations at key conferences in endocrinology

ea0049ep755 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

PCSK9 inhibitors effects on lipid profile in familial hypercholesterolemia in a specific Lipid Unit: experience in first year commercialization

Gonzalez-Molero Inmaculada , Doulatram Viyu , Marin Monserrat Gonzalo , Abuin Jose , Morillas Virginia , Olveira Gabriel , Tinahones Francisco

Objective: Analyse the features of first patients treated with PCSK9 inhibitors in a specific Familial dyslipidemia Unit and the effects on lipid profile in first months of treatment.Material and methods: Data from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors were reviewed. Clinical data, physical examination and analytical data were collected at baseline, one month and 3 months.Results: Da...

ea0049ep808 | Obesity | ECE2017

Evolution of patients with amyotrophic lateral sclerosis followed in a nutrition and endocrinology specific unit during 3 years

Gonzalez-Molero Inmaculada , Gonzalo Monserrat , Doulatram Viyu , Abuin Jose , Tinahones Francisco , Olveira Gabriel

Introduction: A high percentage of patients diagnosed with Amyotrophic Lateral Sclerosis (ALS) have malnutrition. The nutritional treatment in ALS is essential, affecting muscle strength, quality of life and survival.Objective: To describe the nutritional characteristics of patients evaluated in a specific nutritional Unit in patients with ALS during 3 years.Material and methods: A descriptive study of all patients diagnosed with A...

ea0041ep345 | Clinical case reports - Thyroid/Others | ECE2016

Intravenous omega 3 treatment in a pregnant patient with acute pancreatitis and lipoprotein lipase deficiency

Gonzalez-Molero Inmaculada , Bolivar Victoria Contreras , MArin Monserrat Gonzalo , Olveira Gabriel , Dominguez Marta , Tinahones Francisco

Introduction: Acute pancreatitis induced by hypertriglyceridemia is a severe condition and its management is complicated.Case report: We present a case of severe acute pancreatitis induced by hypertriglyceridemia secondary to lipoprotein lipase -LPL- deficiency (188 Gly-Glu mutation, LPL undetectable activity) in a pregnant patient with gestational diabetes.The patient was sent to our Lipid Unit in the 13th gestation’ week. Th...

ea0035p184 | Cardiovascular Endocrinology & Lipid Metabolism | ECE2014

Features of patients with familial hypercholesterolemia treated in a specific lipid unit

Gonzalez-Molero Inmaculada , Vallejo Rosario , Omiste Antonio , Olveira Gabriel , Tinahones Francisco

Objective: To determine the characteristics of patients with familiar hypercholesterolemia studied in a specific unit of lipids.Material and methods: A descriptive study of patients followed in our unit over the last 16 years diagnosed with heterozygous familial hypercholesterolemia (HFH) or familial combined hyperlipidemia (FCH).Results: Data from 111 patients were analyzed: 66 with HFH and 45 with FCH.Featu...

ea0035p397 | Diabetes (epidemiology, pathophysiology) | ECE2014

Features of patients with LADA in a Diabetes Unit

Gonzalez-Molero Inmaculada , Dominguez-Lopez Marta , de Adana Maria Soledad Ruiz , Olveira Gabriel , Tinahones Francisco

Introduction: Latent Autoimmune Diabetes in Adults (LADA) is a form of diabetes which is underdiagnosed and appears to have characteristics of both type 1 (autoimmune in nature) and type 2 diabetes (adult age at onset and initial response to oral hypoglycemic agents).Objective: To study features of patients with LADA diagnosed and treated in our clinic.Material and methods: Retrospective study of patients attended in our clinic in ...

ea0056ep31 | Calcium and Bone | ECE2018

Interventional study to compare two regimens of vitamin D suplementation

Gonzalez Molero Inmaculada , Gonzalo Marin Monserrat , Doulatram Viyei , Abuin Jose , Olveira Gabriel

Introduction: Vitamin D deficiency is very common in our population.It is not clear which is the most effective vitamin D dosing regimen in patients with deficiency.Objective: To compare two vitamin D supplementation regimen in patients with vitamin D deficiency.Material and methods: This is an interventional study: Patients atended in our clinic during May and June 2017 with 25-Hydroxyvitamin D below 30 ng/ml were consecutively se...

ea0049ep756 | Cardiovascular Endocrinology and Lipid Metabolism | ECE2017

Non-lipidic effects of PCSK9 inhibitors in real life

Gonzalez-Molero Inmaculada , Doulatram Viyu , Dominguez Marta , Torralvo Francisco Sanchez , Garcia Ignacio Ruiz , Olveira Gabriel , Tinahones Francisco

Objective: Analyse possible effects on physical examination, blood count, liver and kidney function, and steroidogenic hormones synthesis. Know the satisfaction of patients with the first injectable treatment for hypercholesterolemia approved in our country.Material and methods: Data were collected from patients with heterozygous familial hypercholesterolemia treated with PCSK9 inhibitors. Clinical, physical and analytical data were collected at baseline...

ea0056p805 | Pituitary - Clinical | ECE2018

Long-term outcomes of different treatments for cushing disease: a retrospective study

Molero Inmaculada Gonzalez , Abuin Jose , Marin Monserrat Gonzalo , Doulatram Viyei , Arnes Juan Garcia , Arraez Miguel Angel , Olveira Gabriel

Introduction: Cushing disease (CD) results from excessive exposure to glucocorticoids caused by an adrenocorticotropic hormone–secreting pituitary tumor. Inadequately treated CD is associated with significant morbidity and elevated mortality.Objetive: The study purpose was to describe the long term treatment outcomes for CD patients in our hospital.Methods: Retrospective analysis of the records of 36 patients with Cushing dise...

ea0081ep258 | Diabetes, Obesity, Metabolism and Nutrition | ECE2022

The effect of mimic-mir-21/au@ nanosystem on browning activation: a possible therapeutic tool against obesity

Lhamyani Said , Gentile Adriana-Mariel , Giraldez Perez Rosa Maria , Grueso Elia , Mengual Mesa Maria , Estepa Enrique , Olveira Gabriel , Tinahones Francisco-Jose , Bekay Rajaa El

Background and aim: Obesity is a chronic disease associated with a positive energy balance leading to lipotoxicity, which contributes to the onset of obesity-associated metabolic disorders such as type 2 diabetes and insulin resistance. It’s well known that thermogenesis in brown adipose tissue (BAT) and “browning” of white AT (WAT) increase energy expenditure, thus promoting weight loss and protect against obesity. Recently, the microRNAs (miRNAs) that regulate...

ea0063p184 | Diabetes, Obesity and Metabolism 1 | ECE2019

Diagnosis of type 1 DM in a patient with Hydroxymethylglutaric aciduria: Case report

Doulatram Gamgaram Viyey Kishore , Marin Montserrat Gonzalo , Molero Inmaculada Gonzalez , Fernandez Jose Abuin , Torralvo Francisco Jose Sanchez , Adana Marisol Ruiz de , Fuster Gabriel Olveira

Introduction: Hydroxymethylglutaric aciduria is a rare metabolic disease that is caused by the deficiency of the enzyme 3-hydroxy-3-methylglutaryl-CoA lyase, which participates in the metabolism of leucine and in the formation of ketone bodies. The symptomatology usually occurs in the first two years of life and consists of nausea, vomiting, diarrhea, hypotoniaanddepressed level of consciousness. Metabolic acidosis occurs during crises as a result of the accumulation of metabo...