ea0077p1 | Adrenal and Cardiovascular | SFEBES2021
Devine Kerri
, Russell Clark D
, Moore Shona C
, Thwaites Ryan S
, Hardwick Hayley E
, Oosthuyzen Wilna
, Dunning Jake
, Turtle Lance
, Blanco Giovanny Rodriguez
, Kriegsheim Alex von
, Walker Brian R
, Homer Natalie ZM
, Openshaw Peter JM
, Baillie J Kenneth
, Semple Malcolm G
, Andrew Ruth
, Reynolds Rebecca M
Background: Secretion and metabolism of glucocorticoids and sex steroids is disrupted in critical illness, and may be further disrupted in COVID-19. The host receptor (ACE-2) is expressed in endocrine tissues including adrenal cortex and gonad, and its occupancy may dysregulate the renin-angiotensin system. We hypothesise that severe COVID-19 results in glucocorticoid and sex hormone deficiency, and aldosterone excess.Methods: Plasma was obtained from 27...