Endocrine Abstracts

Mammalian tissues are composed of heterogeneous populations of cells, interacting in highly structured microenvironments to achieve physiologic goals. Understanding the design principles of endocrine tissues organization requires approaches to analyze spatially-resolved sub-populations of cells within the tissue. The mammalian liver consists of hexagonal-shaped lobules, radially polarized by blood flow and morphogens. Key liver are differentially expressed along the lobule axi...

Purpose: Graves’ disease is an autoimmune condition that can cause hyperthyroidism and thyroid eye disease (TED). Definitive treatment is required in approximately 50% patients. Thyroidectomy remains the least chosen primary treatment (2%-18%) despite it having the highest cure rate (>95%). Our aim was to determine the current relationship between patients’ TED and thyroidectomy in a multidisciplinary specialist eye clinic at a tertiary referral centre.<p cla...

Resistance to endocrine treatment develops with time in virtually all patients with metastatic breast cancer (BC), and eventually most of them are treated with chemotheray. Our group and others discovered a group of mutations in the ligand binding domain (LBD) of the estrogen receptor (ER), that are the direct cause of resistance in ~40% of the patients. The most common mutations are Y537S and D538G ER. Clinical data indicate an association between those ER mutations worse pro...

Background: Klotho is a 1012 amino acids transmembrane protein, composed of two internal repeats, KL1 and KL2, that can be cleaved, shed and act as a circulating hormone. Klotho regulates several pathways, including fibroblast growth factor 23 (FGF23), Wnt-β/catenin and the cation channels TRPV and TRPC. Our group and other labs identified klotho as a potent tumor suppressor in breast and pancreatic cancers and that KL1 domain is responsible for this activity. Yet, the me...

Background: Thyroid eye disease (TED) is an autoimmune inflammatory disease associated with Graves’ disease. Rituximab (a monoclonal antibody that depletes B-cells), has recently been shown to be effective in treating TED. There is evidence to support an association with increased TRAbs and TED severity, and one study has demonstrated a fall in TRAbs with rituximab therapy. The aim of this study was to assess the clinical efficacy of low dose rituximab in patients with TE...

Objective: While osteoporotic fractures are reported in up to 40% of post-poliomyelitis adults, clinical guidelines regarding bone mineral density (BMD) testing and best timing for initiating treatment in this population are scarce. We assessed the characteristics of post-poliomyelitis patients, focusing on fracture and osteoporosis as the primary outcomes.Methods: We conducted a cross-sectional retrospective data analysis from medical records of 204 pos...

Introduction: Neonate of patients with type I diabetes (T1D) are at increased risk for neonatal hypoglycemia. It is hypothesized that this is a result of maternal hyperglycemia and subsequent fetal hyperinsulinemia.Aim: The aim of this study was to determine the relationship between clinically significant neonatal hypoglycemia (CS-hypo) and cord-blood c-peptide (CBCP) concentrations in patients with T1D.Materials and methods: This ...