Searchable abstracts of presentations at key conferences in endocrinology

ea0041ep747 | Neuroendocrinology | ECE2016

Limited value of the standard 8-hour water deprivation test in the diagnostic work-up of patients with suspected diabetes insipidus

Trimpou Penelope , Olsson Daniel S. , Ragnarsson Oskar

Background: Diabetes insipidus (DI) is characterized by polyuria and consequently thirst and polydipsia. Excessive water intake can also cause polyuria, i.e. primary polydipsia. It is of utmost importance to differentiate between the two disorders since the treatment is different.Aims: To study the clinical value of the standard 8-hour as well as an extended water deprivation test in patients with polyuria and polydipsia.P...

ea0032p30 | Adrenal cortex | ECE2013

Patients with Addison’s disease have increased frequency of the metabolic syndrome: a case–control study

Bergthorsdottir Ragnhildur , Ragnarsson Oskar , Johannsson Gudmundur

Background: Patient’s with Addison’s disease (AD) have increased morbidity and mortality. Cardiovascular disease is considered the leading cause of death. The aim was to study cardiovascular risk factors in patients with AD.Methods: In a single-centre, case–ontrol study 78 patients (52 women) with AD were compared to 78 controls, matched for gender, age, BMI, and smoking habits. Serum was collected in a fasting state for measurement of lip...

ea0063gp48 | Acromegaly and GH | ECE2019

Prolonged diagnostic delay in acromegaly is associated with long-term morbidity and excess mortality: data from a nationwide study

Esposito Daniela , Ragnarsson Oskar , Johannsson Gudmundur , Olsson Daniel S

Background: Clinical features of acromegaly develop insidiously and the diagnosis is often delayed. However, diagnostic delay (DD) in acromegaly has not been systematically investigated. Our primary aim was to investigate DD in a nationwide cohort of patients with acromegaly. Secondary aim was to study the impact of DD on morbidity and mortality.Methods: Adult patients diagnosed with acromegaly between 2001 and 2013 were identified in the Swedish Nationa...

ea0037gp.21.05 | Pituitary – Diagnosis of Cushing's disease | ECE2015

Mental fatigue and executive dysfunction in patients with Cushing's syndrome in remission

Papakokkinou Eleni , Berglund Peter , Johansson Birgitta , Ragnarsson Oskar

Background: Patients with Cushing’s syndrome (CS) in remission often suffer from impaired quality of life and cognitive dysfunction. Mental fatigue is characterized by mental exhaustion which appears especially during sensory stimulation or following mentally strenuous tasks. Other typical features are long recovery time for restoration of mental energy, irritability, impaired memory and concentration and sensitivity to stress, light and noise. The primary aim of this stu...

ea0070aep65 | Adrenal and Cardiovascular Endocrinology | ECE2020

Patients with adrenal insufficiency have cardiovascular features associated with hypovolemia

Esposito Daniela , Johannsson Gudmundur , Ragnarsson Oskar , Pasquali Daniela

Context: Patients with adrenal insufficiency (AI) have excess mortality and morbidity, mainly due to cardiovascular diseases. The mechanisms for this is unclear.Objective: To assess cardiovascular structure and function in AI patients on conventional replacement therapy and after switching to once-daily, modified-release hydrocortisone (OD-HC).Methods: The analysis included 17 adult AI patients (11 with primary AI, 7 with secondary...

ea0063p1011 | Interdisciplinary Endocrinology 2 | ECE2019

The prevalence of oral glucocorticoid use in doses associated with risk of tertiary adrenal insufficiency

Einarsdottir Margret J , Trimpou Penelope , Olsson Daniel S , Johannsson Gudmundur , Ragnarsson Oskar

Objective: Patients who receive ≥5 mg prednisolone per day, for more than 2–3 weeks, are at risk of developing glucocorticoid (GC) induced adrenal insufficiency (tertiary adrenal insufficiency, 3° AI). The aim of this study was to a) determine the prevalence of GC use in doses that are associated with development of 3° AI, b) assess prescription pattern of short and long-term GC treatment in adults and children, and c) investigate the indication for the GC...

ea0070aep677 | Pituitary and Neuroendocrinology | ECE2020

Carpal tunnel syndrome is common in patients with undiagnosed acromegaly – a swedish nationwide study

Vouzouneraki Konstantina , Esposito Daniela , Mukka Sebastian , Granfeldt Daniel , Ragnarsson Oskar , Dahlqvist Per , Olsson Daniel S

Background: Carpal tunnel syndrome (CTS) is common in patients with acromegaly, with a reported prevalence of 19–64%. We have studied CTS in a large national cohort of patients with acromegaly, and the temporal relationship between the diagnosis of the two diseases.Methods: Retrospective nationwide cohort study including patients diagnosed with acromegaly in Sweden between 2005 and 2017. Patients with acromegaly were identified in the Swedish Natio...

ea0032p703 | Neuroendocrinology | ECE2013

Neurodegenerative and inflammatory biomarkers in cerebrospinal fluid in patients with Cushing's syndrome

Ragnarsson Oskar , Berglund Peter , Eder Detek N , Zetterberg Henrik , Hietala Max A , Blennow Kaj , Johannsson Gudmundur

Background: Patients with Cushing’s syndrome (CS) in long-term remission have impaired cognitive function. Cerebrospinal fluid (CSF) biomarkers are important diagnostic tools in the work-up of patients with cognitive impairment. The aim of this study was to analyze biological markers in CSF from patients with CS in remission. Owing to the overlapping similarities between patients with CS and dementia, i.e. cognitive dysfunction and hypercortisolemia, the main hypothesis w...

ea0056p67 | Adrenal cortex (to include Cushing's) | ECE2018

Adrenal venous sampling in patients with ACTH-independent Cushing’s syndrome

Papakokkinou Eleni , Jakobsson Hugo , Sakinis Augustinas , Muth Andreas , Wangberg Bo , Ehn Olof , Johannsson Gudmundur , Ragnarsson Oskar

Background: ACTH-independent Cushing syndrome (CS) accounts for 15–20% of endogenous CS. Approximately 10% of these patients have bilateral adrenal lesions where the differential diagnoses are primary bilateral adrenal macronodular hyperplasia (PBMAH), primary pigmented nodular adrenal disease (PPNAD), bilateral cortisol producing adenomas or a unilateral cortisol producing adenoma with a contralateral nonfunctioning adenoma. Also, the prevalence of subclinical CS is high...

ea0073aep39 | Adrenal and Cardiovascular Endocrinology | ECE2021

Increasing incidence of primary aldosteronism – yet an underdiagnosed disorder

Gkaniatsa Eleftheria , Ekerstad Eva , Gavric Emanuela , Trimpou Penelope , Olsson Daniel S. , Johannsson Gudmundur , Ragnarsson Oskar

ContextPrimary aldosteronism (PA) is the most common cause of secondary hypertension. Yet, the incidence of PA in the population has not been studied.ObjectiveTo estimate the incidence of PA in western Sweden.Design and methodsPatients who had received a diagnostic code for PA between 1987 and 2016 were identified in the Swedish National Patient Registry. Assessme...