Endocrine Abstracts

A 20-year-old female first presented in 2013 with a six-month history of feeling faint, palpitations, weight loss and oligo-amenorrhoea. She was found to have autoimmune thyrotoxicosis with a fT3 15.2, fT4 43.3, TSH <0.05 and TPO antibodies strongly positive. She was subsequently commenced on Carbimazole 20 mg once a day and was biochemically euthyroid within 6 months. Interestingly, however, she continued to lose weight and remained oligo-amenorrhoeic. ...

A 20-year-old female first presented in 2013 with a six-month history of feeling faint, palpitations, weight loss and oligo-amenorrhoea. She was found to have autoimmune thyrotoxicosis with a fT3 15.2, fT4 43.3, TSH <0.05 and TPO antibodies strongly positive. She was subsequently commenced on Carbimazole 20 mg once a day and was biochemically euthyroid within 6 months. Interestingly, however, she continued to lose weight and remained oligo-amenorrhoeic. ...

Case history: A 20-year-old female first presented to our endocrine clinic in 2013 with a 6-month history of feeling faint, palpitations, weight loss and oligo-amenorrhoea. She was found to have autoimmune thyrotoxicosis with a fT3 of 15.2, fT4 43.3 and TSH <0.05. Her TPO antibodies were strongly positive. She was subsequently commenced on Carbimazole 20 mg once a day and was biochemically euthyroid within 6 months. Interestingly, however, she continued to lose weight and ...

An 86-year old man was admitted to hospital with gradual decline in mobility and leg weakness. Co-morbidities included atrial fibrillation, hypertension and osteoarthritis. The adjusted serum calcium on admission was 3.42 mmol/l; bone profile showed phosphate 0.56 mmol/l, alkaline phosphatase 140 U/l, albumin 34 g/l, parathyroid hormone 21.4 pmol/l. He was vitamin-D replete (68 nmol/l) with normal renal function. The hypercalcaemia was not thought to be due to any medications....

Background: Surgery has a significant role in the management of benign thyroid disease, necessitating pre-operative evaluation and appreciation of possible complications. These include hypoparathyroidism and hypothyroidism. We compared outcomes of our benign thyroid disease patients requiring surgery to national standards set by the British Thyroid Association.Method: Outcomes for patients operated between December 2010 and December 2012 with benign dise...

Traditionally, patients diagnosed with primary hyperparathyroidism present with mild hypercalcaemia and tend to be asymptomatic. Symptomatic patients tend to have severely high calcium and exhibit the classic ’bones, stones, abdominal moans and psychic groans.’ We present a case of a 92-year-old Caucasian gentleman presenting with recurrent falls, postural hypotension and trauma to head and shoulder. X-ray imaging showed small non-specific lucencies in the cervical a...

Objective: Hyponatraemia is the most common electrolyte disturbance encountered in patients – yet its management remains challenging and variable. We audit the management of hyponatraemia in a busy district general hospital, focusing on length of stay (LOS), readmissions and mortality.Methodology: A retrospective analysis was carried out of 30 consecutive inpatients alerted by the hospital biochemistry department with a sodium concentration of &#880...

Case history: We present the case of a 59-year-old gentleman admitted to our hospital in February 2023 with severe hypercalcaemia. He had a background of mild intermittent hypercalcaemia since 2018 (highest 2.73 mmol/l), chronic kidney disease, hypertension, and a recently climbing prostate-specific antigen that had warranted a 2-week-wait Urology referral. On admission, his only symptom was constipation, without weight loss or constitutional symptoms. His parathyroid hormone ...

We present a case of a young female, who was diagnosed with Graves’ thyrotoxicosis in 2019 with very high TSH Receptor antibody. She had a goitre and mild thyroid ophthalmopathy and was commenced on carbimazole. She was followed up in the Endocrine Clinic and carbimazole was titrated according to the clinical and biochemical picture. Her past medical history included epilepsy, generalised anxiety, and emotionally unstable personality disorder. She had difficult social cir...