Searchable abstracts of presentations at key conferences in endocrinology

ea0026p198 | Pituitary | ECE2011

Effects on metabolic parameters after 12-month treatment with a new once-a-week sustained release recombinant growth hormone (LB03002) in adult patients with GH deficiency (GHD)

Roemmler J , Gockel A , Otto B , Bidlingmaier M , Schopohl J

Introduction: GH substitution in GH deficiency (GHD) must be subcutaneously administered daily. Recently, a new sustained release formulation of GH (LB03002) has been developed which has to be injected only once per week. As a sub-study to the double-blind, randomized, placebo-controlled, multicenter, phase-III-study we performed this prospective study to evaluate influences of the new GH formulation on metabolic parameters and the hormones leptin and ghrelin in adult patients...

ea0029oc10.2 | Pituitary Clinical 2 | ICEECE2012

Food intake regulating hormones in adult craniopharyngioma patients

Roemmler J. , Geigenberger V. , Otto B. , Bidlingmaier M. , Dimopoulou C. , Stalla G. , Schopohl J.

Introduction: Patients with craniopharyngeoma often have disturbances of the hypothalamic–pituitary axis and serious comorbidities as obesity. We hypothesized, that the pattern of hormones regulating the nutritional status is worsened in adult patients with craniopharyngioma (CP) compared to adult patients with non-functioning pituitary adenoma (NFPA).Methods: We included 33 patients with CP (m=16, f=17, median age: 48 years (26–7...

ea0014p551 | (1) | ECE2007

Comparison of basal ghrelin and leptin serum levels and after an oral glucose tolerance test in active and inactive acromegalic patients

Roemmler Josefine , Otto Bärbel , Steffin Birgit , Bidlingmaier Martin , Schopohl Jochen

Leptin and ghrelin are correlated to acute and chronic nutritional status. Elevated BMI and fat mass as well as food intake increase leptin levels whereas ghrelin levels are reduced. Ghrelin stimulates growth hormone (GH) secretion. The influence of GH on ghrelin is unclear. Since GH reduces fat mass and is dependent on nutritional status we performed this prospective cross sectional study in order to investigate any interaction between GH, ghrelin and leptin levels in active ...

ea0011p642 | Neuroendocrinology and behaviour | ECE2006

Glucagon-induced suppression of ghrelin secretion is exerted at hypothalamus-pituitary level and is not mediated by an increase in catecholamine secretion

Arafat MA , Perschel F , Otto B , Weickert M , Rochlitz H , Schöfl C , Spranger J , Möhlig M , Pfeiffer AFH

Objective: The mechanisms underlying the well known glucagon-induced satiety effect are unclear. We showed earlier that glucagon induces a remarkable decrease in the orexigenic hormone: ghrelin. It was the aim of the present study to further evaluate the effect of glucagon on ghrelin secretion and the possible site of origin of this effect.Methods: We studied the endocrine and metabolic responses to intramuscular glucagon administration in 23 subjects (1...