Searchable abstracts of presentations at key conferences in endocrinology

ea0022p547 | Neuroendocrinology and Pituitary (<emphasis role="italic">Generously supported by Novartis</emphasis>) | ECE2010

Ghrelin and leptin levels in acromegalic patients treated with pegvisomant

Roemmler Josefine , Otto Baerbel , Ayman Arafat , Martin Bidlingmaier , Jochen Schopohl

Introduction: GH rises dose dependently during treatment with the GH receptor antagonist pegvisomant. Ghrelin stimulates GH secretion. In de novo acromegalic patients with high GH levels, ghrelin levels are lowered and fat mass is reduced. Leptin levels are positively correlated to fat mass. We performed this cross-sectional study to evaluate whether elevated endogenous GH in acromegalic patients on pegvisomant treatment (peg) reduces ghrelin and leptin levels.<p class="ab...

ea0016p368 | Growth factors | ECE2008

Leptin and ghrelin serum levels during an oral glucose tolerance test in patients with growth hormone deficiency with and without growth hormone substitution

Roemmler Josefine , Kuenkler Maren , Otto Baerbel , Bidlingmaier Martin , Schopohl Jochen

In GH deficiency (GHD), fat mass is elevated compared to normal subjects. Leptin is positively related to fat mass, BMI and food intake, while ghrelin correlates negatively. During an oral glucose tolerance test (OGTT), leptin increases in obese subjects and generally does not change in normal weight subjects. Ghrelin decreases during OGTT. We performed a cross-sectional study in order to investigate the influence of GH-substitution on leptin and ghrelin in GHD.<p class="a...

ea0022p713 | Obesity | ECE2010

Gastric inhibitory polypeptide (GIP) suppresses circulating ghrelin in humans: plasma metabolome based correlation network analysis for support of hormone-to- hormone interactions

Rudovich Natalia , Nikiforova Victoria J , Otto Baerbel , Pivovarova Olga , Gogebakan Ozlem , Weickert Martin O , Nauck Michael A , Pfeiffer Andreas F H

Aims: We investigate the influence of GIP on ghrelin secretion in normal glucose tolerant individuals with the use of the firstly applied correlation network analysis on human plasma metabolome data.Methods: To address this issue, we employed a GIP-infusion test and euglycemic- and hyperglycemic glucose clamp experiments combined with infusion of GIP or placebo in a cross-over manner in non diabetic obese male subjects (n=14). Moreover, we firstly...