Searchable abstracts of presentations at key conferences in endocrinology

ea0090p684 | Pituitary and Neuroendocrinology | ECE2023

Fibroblast Activation Protein in Patients with Growth Hormone Deficiency and Acromegaly: Before and After Treatment

Baek Amanda , Arlien-Soborg Mai C. , Kathrine Nissen Pedersen Anne , Jessen Niels , Bjerre Mette , Otto Lunde Jorgensen Jens

Background: It is well-known that growth hormone (GH) potently stimulates collagen turnover and it is associated with fibrosis in several tissues, but the mechanisms involved in GH-stimulated fibrosis are poorly elucidated. Fibroblast activation protein-α (FAPα) is an enzyme that can cleave collagens and is expressed almost only under pathological conditions such as fibrosis. FAPα also cleaves and inactivates fibroblast growth factor 21 (FGF21), which is a circu...

ea0063oc3.4 | Cushing's and acromegaly | ECE2019

Restoration of basal glucose turnover after disease control in acromegaly depends on treatment modality: a prospective, investigator-initiated trial

Arlien-Soborg Mai C , Dal Jakob , Madsen Michael , Hogild Morten , Hjelholt Astrid , Jessen Niels , Moller Niels , Otto Lunde Jorgensen Jens

Background: Growth Hormone (GH) reversibly suppresses insulin-stimulated glucose uptake in skeletal muscle, but less is known about GH effects on glucose metabolism in the basal state. Somatostatin suppresses GH as well as insulin, and may also exert direct effects in skeletal muscle. This may have therapeutic implications in the treatment of acromegalic patients with a somatostatin analogue (SA).Aim: To study basal and insulin-stimulated glucose metabol...

ea0090p19 | Adrenal and Cardiovascular Endocrinology | ECE2023

RESCUE: Effect of supplemental hydrocortisone during stress in glucocorticoid-induced adrenal insufficiency; A study protocol for a multicentre, randomised, double blinded, placebo-controlled clinical trial

Willemoes Borresen Stina , Boggild Hansen Simon , Al-Jorani Hajir , Sofie Bislev Lise , Bue Bjorner Jakob , Brun Boesen Victor , Lehmann Christensen Louise , Fenger Dreyer Anja , Glintborg Dorte , Christian Jensen Richard , Thurmann Jorgensen Nanna , Klose Marianne , Louise Lund Marie , Stankovic Jelena , Tei Randi , Watt Torquil , Otto Lunde Jorgensen Jens , Skovsager Andersen Marianne , Feldt-Rasmussen Ulla

Background: Long-term, low-dose prednisolone treatment (≤5mg/day) is associated with adrenal insufficiency in >33% of patients. Nevertheless, the clinical consequences of glucocorticoid-induced adrenal insufficiency in patients receiving ongoing low-dose glucocorticoid treatment are unknown. Current clinical guidelines do not recommend routine evaluation of adrenal function during low-dose glucocorticoid treatment, and patients are not routinely instructed to increase gl...