Searchable abstracts of presentations at key conferences in endocrinology

ea0010p81 | Steroids to include Cushing's | SFE2005

Association of an FC receptor-like 3 haplotype with autoimmune Addison’s disease suggests an alternative pathogenic allele at the locus

Owen C , Eden J , Jennings C , Wilson V , Cheetham T , Pearce S

The common autoimmune endocrinopathies are caused by susceptibility alleles at several genetic loci including MHC, CTLA4, PTPN22 and probably several others. Many of these susceptibility alleles are shared between several different autoimmune disorders including type 1 diabetes, autoimmune thyroid diseases and rheumatoid arthritis. In recent months a novel susceptibility locus was identified in the 5’ end of the Fc receptor-like 3 (FCRL3) gene ...

ea0005p255 | Thyroid | BES2003

Preliminary evidence for genetic heterogeneity in the autoimmune polyendocrinopathy and enteropathy syndrome (IPEX)

Owen C , Jennings C , Imrie H , Lachaux A , Bridges N , Cheetham T , Pearce S

The immune dysregulation, polyendocrinopathy and enteropathy, X-linked syndrome (IPEX), is a rare and devastating condition of male infants. Immune mediated diabetes and enteropathy occur before 6 months of age and other manifestations include hypothyroidism, recurrent infections and eczema. In 2001, IPEX was mapped to Xp11, an orthologous region to that for the murine model of T cell dysregulation, scurfy, and mutations in the forkhead transcription factor gene, FOXP3,...

ea0005p258 | Thyroid | BES2003

The W546X mutation of the thyrotropin receptor gene: Potential major contributor to thyroid dysfunction in a caucasian population

Jordan N , Willliams N , Gregory J , Evans C , Owen M , Ludgate M

Congenital hypothyroidism (CH) occurs in approximately 1 in 3000 individuals. Rapid detection and treatment by neonatal screening and administration of T4, is essential to prevent severe mental retardation and impaired growth.We report on two Welsh siblings, detected by neonatal screening, which had normal sized and placed glands but negative isotope uptake. Mutations resulting in CH are known to occur in 11 known genes, given the clinical presentation, we investigated the...