Searchable abstracts of presentations at key conferences in endocrinology

ea0034p259 | Obesity, diabetes, metabolism and cardiovascular | SFEBES2014

Decrums disease: an unusual case of bilateral adrenal lipomas

Hannon Anne Marie , Owens Lisa , O'Halloran Domhnall

Decrum’s disease or adiposis dolorasa is a rare progressive syndrome of unknown aetiology. It is characterised by painful fatty deposits, general obesity, weakness and unexplained emotional disturbance.1We describe a case of a 55-year-old man who presented with pneumonia. On examination he was noted to be overweight and have multiple skin nodules. His chest X-ray was abnormal; he underwent further workup with a CT thorax/abdomen/pelvis. T...

ea0062p36 | Poster Presentations | EU2019

A case of meningioma associated with long-term use of cyproterone acetate

Owens Lisa , Halliday Jane , Kerr Richard , Franks Stephen

Case history: A 58 year old woman presented to her GP when her family members noted prominence of her left eye. She had a background history of polycystic ovary syndrome (PCOS). Her main symptom of PCOS was hirsutism. She had been treated initially with the combined oral contraceptive pill ‘Dianette’ (ethinyloestradiol/cyproterone) but had also been treated intermittently with varying doses of 25–100 mg cyproterone acetate (CPA) 10 days/cycle. Post menopause she...

ea0037ep394 | Diabetes (pathiophysiology & epitemiology) | ECE2015

10 years of improving outcomes for women with pre-gestational diabetes

Owens Lisa , Carmody Louise , Egan Aoife , Dunne Fidelma

Pregnancy for women with type 1 or type 2 diabetes is a high-risk time. The Atlantic diabetes in pregnancy (DIP) programme aims to provide coordinated, optimal evidence-based clinical care for women with diabetes over five hospital centres in the West of Ireland. After previously auditing pregnancy outcomes in 2008 and again in 2011 we now look at our 10-year outcomes. Changes in clinical care delivery that have occurred over that time include; the provision of dedicated combi...

ea0077p233 | Reproductive Endocrinology | SFEBES2021

In vitro effects of dihydrotestosterone (DHT) on gonadotropin receptor function and steroidogenesis in human granulosa lutein cells

Anujan Priyanka , Owens Lisa , Alro Botkjaer Jane , Hanyaloglu Aylin , Hardy Kate , Franks Stephen

Polycystic ovary syndrome (PCOS) is a multifactorial, complex endocrine disorder affecting a significant proportion of the global population. Hyperandrogenism is a key feature of PCOS patients. Aberrant secretion and/or action of gonadotropins have been implicated in PCOS, but, to date, we have only limited knowledge of how these factors may interact in the aetiology of PCOS. We hypothesised that excess androgens may cause aberrant gonadotropin activity and therefore sought to...

ea0077p234 | Reproductive Endocrinology | SFEBES2021

Reproductive health disturbance in the era of the COVID-19 pandemic

Maher Michelle , Keeffe Aedin O’ , Phelan Niamh , Ann Behan Lucy , Collier Sonya , Hevey David , Owens Lisa

Background: The combined effect of the COVID-19 pandemic and associated restrictions have adversely affected population mental health. Periods of psychological distress can induce menstrual dysfunction. We previously demonstrated a significant disruption in women’s reproductive health during the first 6 months of the pandemic. The present study investigates longer term reproductive and mental health disturbances.Materials and Methods: An online surv...

ea0056gp130 | Female Reproduction | ECE2018

Alterations in gonadotropin receptors and signal activation in granulosa lutein cells from women with polycystic ovary syndrome

Owens Lisa , Christopolous Georgios , Khanjani Shirin , Hardy Kate , Lavery Stuart , Franks Stephen , Hanyaloglu Aylin

Background: Polycystic ovary syndrome (PCOS) is a common endocrine disorder, affecting 5–10% of women of reproductive age. The underlying pathogenesis is complex and incompletely understood. There is evidence that gonadotropin and gonadotropin receptor action play a role in the pathogenesis of PCOS with genome wide association studies in PCOS also implicating altered gonadotropin action in the aetiology of PCOS. Furthermore, our recent studies have demonstrated that gonad...

ea0073s13.2 | Symposium 13: TGF-β signalling in ovaries in women with PCOS | ECE2021

LH-receptor activity and interaction with TGF-β family members in women with PCOS

Owens Lisa , Kristensen Stine Gry , Lerner Avi , Hanyaloglu Aylin , Hardy Kate , Andersen Claus Yding , Franks Stephen

The luteinising hormone/chorionic gonadotropin receptor (LHCGR) plays an essential role in ovarian follicular function, mediating the action of LH on theca cell steroidogenesis and, in the preovulatory follicle, on granulosa cell (GC) steroid production and the ovulatory cascade. Following ovulation, LH (and CG) are responsible for maintenance and function of the corpus luteum. Arrested antral follicle development in PCOS is characterised by premature responsiveness of GCs to ...

ea0086p120 | Reproductive Endocrinology | SFEBES2022

Female reproductive health disturbance associated with the COVID-19 pandemic persists despite improving mental health- a longitudinal observational study

Lonergan Eibhlin , Maher Michelle , Collier Sonya , Ann Behan Lucy , Phelan Niamh , Hevey David , Owens Lisa

Background: The COVID-19 pandemic has adversely affected population mental health. In April 2021 we conducted an observational study which demonstrated disruption in women’s reproductive and mental health during the first year of the pandemic. Our objective therefore was to perform follow up studies in this cohort of women at 6-monthly intervals, to assess the longer term enduring impact of the pandemic on reproductive and mental health.Materials/Me...

ea0086p123 | Reproductive Endocrinology | SFEBES2022

Androgen receptor splice-variants in granulosa-lutein cells of women with polycystic ovary syndrome (PCOS)

Anujan Priyanka , Lerner Avi , Owens Lisa , Markou Andrea , Hardy Kate , Hanyaloglu Aylin , Bevan Charlotte , Franks Stephen

Defects in any of the four functional domains of the androgen receptor (AR) (resulting from loss-of-function or gain-of-function mutations), may affect androgen action. Specific AR splice variants have been reported in women with PCOS (Wang et al, PNAS 2015 112 4743). In this study we sought to identify AR splice variants in granulosa-lutein (GL) cells of women with and without PCOS and to assess their functional significance. GL cells were ...

ea0059oc6.4 | Neuroendocrinology and Reproduction | SFEBES2018

Kisspeptin receptor activity in human granulosa lutein cells

Owens Lisa , Abbara Ali , Lerner Avi , Christopoulous Georgios , Lavery Stuary , Hardy Kate , Dhillo Waljit , Hanyaloglu Aylin , Franks Stephen

Background: Kisspeptin stimulates gonadotropin secretion indirectly by stimulation of hypothalamic GnRH neurons. Kisspeptin and kisspeptin receptor, a G-protein coupled receptor (GPCR), are also expressed in the human ovary, but their direct actions on ovary, if any, are unclear.Objectives: To examine the direct actions of kisspeptin on granulosa lutein cells (GL cells) and the role of kisspeptin in steroidogenesis.Materials and me...