Searchable abstracts of presentations at key conferences in endocrinology

ea0007p276 | Clinical case reports | BES2004

The evolution of diabetes insipidus in a man with multiple pathology in the sacrum

Rajeswaran C , Oxynos C , Belchetz P

A 45 year old male was referred in November 2001 to the endocrine clinic with the complaints of sudden onset marked thirst, polyuria with nocturia (six times) for two months. His past medical history includes a diagnosis of solitary sacral plasmacytoma diagnosed in 1998, based on bone marrow aspirate and trephine in the presence of the paraproteinaemia. He was successfully treated with radiotherapy. There has been no history of head injury and has not been on regular medicatio...

ea0007p177 | Reproduction | BES2004

Oral tibolone combined with testosterone as a potential male contraceptive: pharmacodynamic study examining additive effects in suppression of pituitary-testicular axis

Oxynos C , Wu F

BACKGROUND: Hormonal male contraception is based on the reversible suppression of LH and FSH resulting in intratesticular testosterone depletion with subsequent spermatogenic arrest and infertility. Tibolone, a unique synthetic steroid with mixed progestational, androgenic and oestrogenic activities, has been shown to suppress gonadotrophins, inhibit ovulation and postmenopausal hot flushes in women. HYPOTHESIS: We hypothesise that the hybrid anti-gonadotrophic action of Tibol...

ea0007p282 | Clinical case reports | BES2004

Pituitary sarcoidosis with disappearing mass: case report

Oxynos C , Rajeswaran C , Belchetz P

A 37 year old Afro-Caribbean woman, with panhypopituitarism secondary to a pituitary macroadenoma was referred from a DGH physician to the neurosurgeons. She complained of headaches and blurred vision. Initial presentation was with malaise, weight loss, vomiting, abdominal pain, and secondary amenorrhoea. She was found to have panhypopituitarism and was on thyroxine and hydrocortisone replacement therapy. Abdominal CT had showed widespread axillary para aortic and iliac lympha...

ea0012p107 | Reproduction | SFE2006

Prevalence of assay interference in women with high serum testosterone levels

Ravikumar B , Handley G , Weaver JU , Oxynos C , Narayanan KR

Index case and aimsA 26 year old woman was referred to our endocrine clinic with infertility and raised testosterone levels. Clinical examination was completely normal, with no hirsuitism or virilizing features. She had normal gonadotropin and SHBG levels, but had elevated testosterone (6.6 nmol/l (0.5–2.8) and dehydroepiandrosterone sulphate (DHEA-S) levels (13.5 umol/l (1.4–11.1)). To exclude the possibility of interference in our direct assa...

ea0003p225 | Reproduction | BES2002

Oral clatharate-DHEA as a potential form of androgen replacement in hypogonadal men. A phase 2, open label, placebo controlled, parallel group pharmacokinetic study

Oxynos C , Phillips J , Laing I , Saad F , Wu F

BACKGROUND: DHEA and DHEAS, can be converted into Androstenedione, T and DHT as well as oestrogens by peripheral tissues. In normal men the conversion rate of IV-infused radiolabelled DHEAS to T is only 0.7%. In hypogonadal men, this conversion rate may be increased. We hypothesise that a pharmacological dose of orally administered DHEA may be able to raise plasma T into the normal range in hypogonadal men. METHODS: Local Ethical Committee Approval was obtained. Two groups (n=...

ea0005p210 | Reproduction | BES2003

Comparison between azoospermic responders and oligozoospermic non-responders to sex steroidal contraception: A pharmacogenetics study examining the androgen receptor, CYP17, LHbeta and 5alpha-reductase-2 genes

Oxynos C , Thakker N , Hewitt C , Southern L , Anderson R , Huhtaniemi I , Yong E , Wu F

BACKGROUND: Male steroidal contraceptive regimens achieve azoospermia in 60-90% of Caucasians. The mechanisms underlying this heterogeneity in response are not clear. The aim of this retrospective study was to examine a number of polymorphisms in genes involved in androgen metabolism and action, in azoospermic responders (n=73) and oligozoospermic non-responders (n=44) from previous contraceptive trials. METHODS: Local Ethical Committee approval was obtained. DNA was extracted...