Endocrine Abstracts

Objective: Agouti related peptide (AgRP), the endogenous antagonist of the melanocortin 3 and 4 receptors, is expressed at high levels in the arcuate nucleus of the hypothalamus. Some studies have demonstrated that intracerebroventricular AgRP administration increases plasma LH, FSH, testosterone levels. It also increases hypothalamic LHRH release in vitro, an effect that can be prevented by addition of melanocyte stimulating hormone. These findings suggest that AgRP ma...

Background: Parathyroid hormone-related protein (PTHrP) was discovered as a tumor product. It is also one of the complex epithelial and mesenchymal interaction signal mediator in breast development. An increase in the prevalence of malignancy in patients with Klinefelter’s syndrome, but not in patients with idiopathic gynecomastia has been previously reported. PTHrP may play a critical role in the development or progression of breast cancer.Aim: We ...

Up to date, many studies were performed regarding the relationship between obesity and inflammation, and exophthalmos which is developed in thyroid-associated ophthalmopathy (Graves’ ophthalmopathy). Several studies suggest that transforming orbital preadipocytes into adipocytes may cause exophthalmos because of the inflammation. Therefore, we examined the relationship exophthalmos and obesity which is also called low-grade systemic inflammation. We investigated the relat...

Context: FABP4 (adipocyte-specific fatty acid-binding protein 4, also known as aP2) is a cytoplasmic lipid chaperon involved in lipid metabolism, glucose homeostasis, and the regulation of inflammatory response. Its expression is limited to adipocytes, macrophages, skeletal muscle, and bronchial epithelia. Recently, a polymorphic allele of the aP2 promoter (−87T→C) has been shown to be associated with decreased FABP4 expression in fat tissue, lowered triglyc...

Tumors of thyroid gland are one of the most prevalent forms of human cancers. Despite the various molecular mechanisms, mutations or polymorphisms of p53 have a potential role in the development and/or progression of human malignancies including thyroid. A common variation in p53 that results in adenine to proline change in codon 72 has been identified as a predisposing factor for various cancers since controversial results have been reported. In this study, we investigated co...