Searchable abstracts of presentations at key conferences in endocrinology

ea0056p1149 | Thyroid cancer | ECE2018

The mitochondrial DNA control region might have useful diagnostic and prognostic biomarkers for thyroid tumors

Bircan Rifat , Gozu Hulya Iliksu , Ulu Esra , Sarikaya Sukran , Sirin Duygu Yasar , Ozcelik Serhat , Aral Cenk

Background: It is currently present in the literature that mitochondrial DNA (mtDNA) defects are associated with a great number of diseases including cancers. The role of mitochondrial DNA (mtDNA) mutations/variations in the development of thyroid cancers is a highly controversial topic. In this study, we aimed to investigate the role of mt-DNA control region (CR) variations in thyroid tumor occurrence and the influence of mtDNA haplogroups on susceptibility t...

ea0056p970 | Male Reproduction | ECE2018

A case of Wolfram syndrome with primary gonadal insufficiency

Ozcelik Serhat , Sariyadin Mehmet , Aydin Bunyamin , Temiz Sibel , Caglayan Kenan , Celik Mehmet , Kizilgul Muhammed , Gozu Hulya Iliksu

Introduction: Wolfram syndrome is characterized by diabetes mellitus (DM), diabetes insipidus (DI), optic atrophy and sensorineural deafness. DM is the first manifestation and optic atrophy also onsets in the first decade of life. The onsets of DI and sensorineural deafness are in the second decade, urinary tract abnormalities are in the third decade and neurologic abnormalities are in the fourth decade respectively. Hypogonadotrophic hypogonadism is a usual manifestation of t...

ea0056p1151 | Thyroid cancer | ECE2018

Determination of the BRAF V600E mutation prevalance at papillary thyroid carcinomas (PTCs) in Turkish population

Ozcelik Serhat , Bircan Rifat , Sarikaya Sukran , Aydin Busra , Celik Mehmet , Dayan Akin , Karadayi Nimet , Tutuncu Yasemin , Cengiz Hasret , Ozcelik Melike , Gozu Hulya Iliksu

Introduction: BRAF V600E substitution is one of the most common mutation in PTC in different populations, and is associated with poor prognosis of the classical variant of PTC (CVPTC) such as extrathyroidal expansion, vascular invasion, lymph node metastasis and recurrence of the disease. The purpose of this study is to determine the prevalence of BRAF V600E mutation in subcell- types of the PTCs in Turkish population.Materials and methods: A total of 19...