Searchable abstracts of presentations at key conferences in endocrinology

ea0014p264 | (1) | ECE2007

Exophthalmos and its relation to adipokines in obese men

Caglayan Sinan , Ozisik Gokhan , Unal Melih , Ozcan Omer , Ozata Metin

Up to date, many studies were performed regarding the relationship between obesity and inflammation, and exophthalmos which is developed in thyroid-associated ophthalmopathy (Graves’ ophthalmopathy). Several studies suggest that transforming orbital preadipocytes into adipocytes may cause exophthalmos because of the inflammation. Therefore, we examined the relationship exophthalmos and obesity which is also called low-grade systemic inflammation. We investigated the relat...

ea0014p290 | (1) | ECE2007

Elevated plasma FABP4 (aP2) levels in hypothyroidism: potential implication for accelerated atherosclerosis

Ozisik Gokhan , Caglayan Sinan , Gultepe Mustafa , Ozata Metin

Context: FABP4 (adipocyte-specific fatty acid-binding protein 4, also known as aP2) is a cytoplasmic lipid chaperon involved in lipid metabolism, glucose homeostasis, and the regulation of inflammatory response. Its expression is limited to adipocytes, macrophages, skeletal muscle, and bronchial epithelia. Recently, a polymorphic allele of the aP2 promoter (−87T→C) has been shown to be associated with decreased FABP4 expression in fat tissue, lowered triglyc...

ea0014p379 | (1) | ECE2007

Association of p53 codon 72 polymorphism with thyroid cancer

Caglayan Sinan , Aral Cenk , Massaumilary Sirin , Ozisik Gokhan , Baloglu Huseyin , Akkiprik Mustafa , Ozer Ayse , Ozata Metin

Tumors of thyroid gland are one of the most prevalent forms of human cancers. Despite the various molecular mechanisms, mutations or polymorphisms of p53 have a potential role in the development and/or progression of human malignancies including thyroid. A common variation in p53 that results in adenine to proline change in codon 72 has been identified as a predisposing factor for various cancers since controversial results have been reported. In this study, we investigated co...