Searchable abstracts of presentations at key conferences in endocrinology

ea0012p51 | Diabetes, metabolism and cardiovascular | SFE2006

High glucose regulates SGK1 and alpha-ENAC expression in a human cortical collecting duct cell line

Bland R , Hills CE , Ronco PM , Bennett J , Squires PE

Alterations in sodium reabsorption in collecting duct epithelium can have severe implications for the normal function of the nephron and may precipitate the development of secondary hypertension. One of the principal protein kinases involved in sodium transport in the nephron is the serum and glucocorticoid regulated kinase (SGK1) that mediates translocation and insertion of the epithelial sodium channel (ENaC) into the plasma membrane. SGK1 appears to be increased in the kidn...